A neural network model that learns differences in diagnosis strategies among radiologists has an improved area under the curve for aneurysm status classification in magnetic resonance angiography image series
National Institute of Radiological Sciences, QST（量子科学技术研究开发机构放射线医学综合研究所）；MNES corporation（MNES公司）；QST Hospital, QST（量子科学技术研究开发机构医院）
Purpose: To construct a neural network model that can learn the different diagnosing strategies of radiologists to better classify aneurysm status in magnetic resonance angiography images. Materials and methods: This retrospective study included 3423 time-of-flight brain magnetic resonance angiography image series (subjects: male 1843 [mean age, 50.2 +/- 11.7 years], female 1580 [50.8 +/- 11.3 years]) recorded from November 2017 through January 2019. The image series were read independently for aneurysm status by one of four board-certified radiologists, who were assisted by an established deep learning-based computer-assisted diagnosis (CAD) system. The constructed neural networks were trained to classify the aneurysm status of zero to five aneurysm-suspicious areas suggested by the CAD system for each image series, and any additional aneurysm areas added by the radiologists, and this classification was compared with the judgment of the annotating radiologist. Image series were randomly allocated to training and testing data in an 8:2 ratio. The accuracy of the classification was compared by receiver operating characteristic analysis between the control model that accepted only image data as input and the proposed model that additionally accepted the information of who the annotating radiologist was. The DeLong test was used to compare areas under the curves (P < 0.05 was considered significant). Results: The area under the curve was larger in the proposed model (0.845) than in the control model (0.793), and the difference was significant (P < 0.0001). Conclusion: The proposed model improved classification accuracy by learning the diagnosis strategies of individual annotating radiologists.
Academy for Engineering and Technology, Fudan University（复旦大学工程与应用技术研究院）；Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences（中国科学院苏州生物医学工程技术研究所）；Department of Radiology, Huashan Hospital, Fudan University（复旦大学附属华山医院放射科）；Biomedical Engineering, Xuzhou Medical University（徐州医科大学生物医学工程）
Background:Subarachnoid hemorrhage caused by ruptured cerebral aneurysm often leads to fatal consequences.However,if the aneurysm can be found and treated during asymptomatic periods,the probability of rupture can be greatly reduced.At present,time-of-flight magnetic resonance angiography is one of the most commonly used non-invasive screening techniques for cerebral aneurysm,and the application of deep learning technology in aneurysm detection can effectively improve the screening effect of aneurysm.Existing studies have found that three-dimensional features play an important role in aneurysm…
Center for Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School（麻省总医院与哈佛医学院高级医学计算与分析中心）；Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School（麻省总医院与哈佛医学院戈登医学影像中心）；Department of Radiology, Massachusetts General Hospital and Harvard Medical School（麻省总医院与哈佛医学院放射科）
Purpose: To develop CADIA, a supervised deep learning model based on a region proposal network coupled with a false-positive reduction module for the detection and localization of intracranial aneurysms (IA) from computed tomography angiography (CTA), and to assess our model's performance to a similar detection network. Methods: In this retrospective study, we evaluated 1,216 patients from two separate institutions who underwent CT for the presence of saccular IA>=2.5 mm. A two-step model was implemented: a 3D region proposal network for initial aneurysm detection and 3D DenseNetsfor false-pos…
Weakly Supervised Intracranial Aneurysm Detection and Segmentation in MR angiography via Multi-task UNet with Vesselness Prior
Department of Computer Science and Software Engineering, Concordia University, Montréal, Canada（计算机科学与软件工程系，康科迪亚大学）；NeuroRx Research, Montréal, Canada（NeuroRx研究公司）；Department of Electrical and Computer Engineering, Concordia University, Montréal, Canada（电气与计算机工程系，康科迪亚大学）
DeepVox and SAVE-CT: a contrast- and dose-independent 3D deep learning approach for thoracic aorta segmentation and aneurysm prediction using computed tomography scans
Albert Einstein Israeli Institute of Education and Research（阿尔伯特·爱因斯坦以色列教育与研究学院）；Health Innovation Techcenter（健康创新技术中心）；Department of Radiology（放射科）；Department of Vascular and Endovascular Surgery（血管与血管外科）
本研究提出 DeepVox 分割模型和 SAVE-CT 分类模型，在独立于对比剂和剂量的 3D CT 扫描上实现全自动胸主动脉瘤筛查，分割和分类测试集表现优异，有望降低死亡率并优化放射科评估队列。
University of Sheffield（谢菲尔德大学）；Sheffield Teaching Hospitals NHS Foundation Trust（谢菲尔德教学医院NHS基金会信托）；INSIGNEO, Institute for In Silico Medicine, University of Sheffield（谢菲尔德大学INSIGNEO计算医学研究所）；NIHR Sheffield Biomedical Research Centre, University of Sheffield（谢菲尔德大学NIHR谢菲尔德生物医学研究中心）
Purpose: Lung disease assessment in precapillary pulmonary hypertension (PH) is essential for appropriate patient management. This study aims to develop an artificial intelligence (AI) deep learning model for lung texture classification in CT Pulmonary Angiography (CTPA), and evaluate its correlation with clinical assessment methods. Materials and Methods: In this retrospective study with external validation, 122 patients with pre-capillary PH were used to train (n=83), validate (n=17) and test (n=10 internal test, n=12 external test) a patch based DenseNet-121 classification model. "Normal", …
Nuance Communications Inc.（Nuance通信公司）；MGH and BWH Center for Clinical Data Science（麻省总医院与布莱根妇女医院临床数据科学中心）；Brigham and Women’s Hospital (BWH)（布莱根妇女医院）；Massachusetts General Hospital (MGH)（麻省总医院）
We propose a deep learning-based technique for detection and quantification of abdominal aortic aneurysms (AAAs). The condition, which leads to more than 10,000 deaths per year in the United States, is asymptomatic, often detected incidentally, and often missed by radiologists. Our model architecture is a modified 3D U-Net combined with ellipse fitting that performs aorta segmentation and AAA detection. The study uses 321 abdominal-pelvic CT examinations performed by Massachusetts General Hospital Department of Radiology for training and validation. The model is then further tested for general…
Lausanne University Hospital and University of Lausanne（洛桑大学医院和洛桑大学）；Center for Biomedical Imaging（生物医学成像中心）；Ecole Polytechnique Fédérale de Lausanne（洛桑联邦理工学院）
A commonly adopted approach to carry out detection tasks in medical imaging is to rely on an initial segmentation. However, this approach strongly depends on voxel-wise annotations which are repetitive and time-consuming to draw for medical experts. An interesting alternative to voxel-wise masks are so-called "weak" labels: these can either be coarse or oversized annotations that are less precise, but noticeably faster to create. In this work, we address the task of brain aneurysm detection as a patch-wise binary classification with weak labels, in contrast to related studies that rather use s…
The Chinese University of Hong Kong, Shenzhen（香港中文大学（深圳））；Shenzhen Research Institute of Big Data（深圳大数据研究院）；The First Affiliated Hospital of Jinan University（暨南大学附属第一医院）
Automatic segmentation of hepatocellular carcinoma (HCC) in Digital Subtraction Angiography (DSA) videos can assist radiologists in efficient diagnosis of HCC and accurate evaluation of tumors in clinical practice. Few studies have investigated HCC segmentation from DSA videos. It shows great challenging due to motion artifacts in filming, ambiguous boundaries of tumor regions and high similarity in imaging to other anatomical tissues. In this paper, we raise the problem of HCC segmentation in DSA videos, and build our own DSA dataset. We also propose a novel segmentation network called DSA-LT…
National Chiao-Tung University（国立交通大学）；National Cheng Kung University Hospital（国立成功大学附属医院）；College of Medicine, National Cheng Kung University（国立成功大学医学院）
This study was conducted to develop a computer-aided detection (CAD) system for triaging patients with pulmonary embolism (PE). The purpose of the system was to reduce the death rate during the waiting period. Computed tomography pulmonary angiography (CTPA) is used for PE diagnosis. Because CTPA reports require a radiologist to review the case and suggest further management, this creates a waiting period during which patients may die. Our proposed CAD method was thus designed to triage patients with PE from those without PE. In contrast to related studies involving CAD systems that identify k…
Intracranial aneurysms (IAs) are generally asymptomatic and thus often discovered incidentally on angiographic scans like 3D DSA, CTA and MRA. Skilled radiologists achieved a sensitivity of 88% by means of visual detection, which seems inadequate considering that prevalence of IAs in general population is 3-5%. Deep learning models trained and executed on angiographic scans seem best-suited for IA detection, however, reported performances across different modalities is currently insufficient for clinical application. This paper presents a novel modality agnostic method for detection of IAs. Fi…
Cross-modality image synthesis from TOF-MRA to CTA using diffusion-based models
Charité – Universitätsmedizin Berlin（柏林夏里特医学院）；Freie Universität Berlin（柏林自由大学）；Humboldt-Universität zu Berlin（柏林洪堡大学）；Mie University Graduate School of Medicine（三重大学医学院）；Mie Chuo Medical Center（三重中央医疗中心）
Unified-protocol voxel-level pulmonary embolism annotations for three public CT angiography datasets
Technical University of Munich (TUM)（慕尼黑工业大学）；Munich Center for Machine Learning (MCML)（慕尼黑机器学习中心）；The Affiliated Hospital of Xuzhou Medical University（徐州医科大学附属医院）；The Third Affiliated Hospital of Soochow University（苏州大学附属第三医院）；The Affiliated Taizhou People’s Hospital of Nanjing Medical University（南京医科大学附属泰州人民医院）
Coronary artery disease (CAD) has posed a leading threat to the lives of cardiovascular disease patients worldwide for a long time. Therefore, automated diagnosis of CAD has indispensable significance in clinical medicine. However, the complexity of coronary artery plaques that cause CAD makes the automatic detection of coronary artery stenosis in Coronary CT angiography (CCTA) a difficult task. In this paper, we propose a Transformer network (TR-Net) for the automatic detection of significant stenosis (i.e. luminal narrowing > 50%) while practically completing the computer-assisted diagnosis …
Toward an Integrated Decision Making Framework for Optimized Stroke Diagnosis with DSA and Treatment under Uncertainty
Institut Teknologi Sepuluh Nopember (ITS)（十十一月科技学院（ITS））；Universitas Islam Negeri (UIN) Syarif Hidayatullah（赛义德·希达亚图拉伊斯兰国立大学）；Stanford University（斯坦福大学）
Hessian-Based Lightweight Neural Network HessNet for State-of-the-Art Brain Vessel Segmentation on a Minimal Training Dataset
Institute of Artificial Intelligence, M.V.Lomonosov Moscow State University（人工智能研究所，莫斯科国立大学）；Laboratory of Analysis of Semantics, Centre for Language and Semantics Technologies, Faculty of Computer Science, HSE University（语义分析实验室，语言与语义技术中心，计算机科学系，高等经济大学）；Neurosputnik LLC（Neurosputnik公司）；Mechanics and Mathematics Faculty, M.V.Lomonosov Moscow State University（力学与数学系，莫斯科国立大学）；International Laboratory of Algebraic Topology and Its Applications, Faculty of Computer Science, HSE University（国际拓扑学及其应用实验室，计算机科学系，高等经济大学）
