非标准MBI系统的平行孔和针孔有限角层析成像重建
Limited Angle Tomography reconstruction for non-standard MBI system by means of parallel-hole and pinhole optics
摘要：
本工作的目的是研究一种新的分子乳腺成像（MBI）设备的重建性能，用于乳腺癌的早期诊断，在有限角度断层扫描（LAT），通过使用两个不对称的探测器头与不同的准直器。探测器在反平行观察方向上彼此面对，并且温和地压缩乳房体模，它们能够使用专用的最大似然期望最大化（ML-EM）算法仅用有限数量的投影来重建体模的内部肿瘤。本文简要介绍了该系统、MBI系统以及采用Geant 4层析成像发射应用软件（GATE）的蒙特卡罗模拟器。MBI系统的模型已在IDL（交互式数据可视化）中实现，以评估系统的最佳LAT配置及其重建能力，通过改变肿瘤的大小，深度和摄取。LAT设置在真实和模拟的配置，以及ML-EM方法和初步的重建结果，进行了讨论。
英文摘要：
The purpose of the present work is the study of reconstruction properties of a new Molecular Breast Imaging (MBI) device for the early diagnosis of breast cancer, in Limited Angle Tomography (LAT), by using two asymmetric detector heads with different collimators. The detectors face each other in anti-parallel viewing direction and, mild-compressing the breast phantom, they are able to reconstruct the inner tumour of the phantoms with only a limited number of projections using a dedicated maximum-likelihood expectation maximization (ML-EM) algorithm. Phantoms, MBI system, as well as Monte Carlo simulator using Geant 4 Application for Tomographic Emission (GATE) software, are briefly described. MBI system's model has been implemented in IDL (Interactive Data Visualization), in order to evaluate the best LAT configuration of the system and its reconstruction ability by varying tumour's size, depth and uptake. LAT setup in real and simulated configurations, as well as the ML-EM method and the preliminary reconstruction results, are discussed.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
