Deep Transfer Convolutional Neural Network and Extreme Learning Machine for Lung Nodule Diagnosis on CT images

Level set image segmentation with velocity term learned from data with applications to lung nodule segmentation

Purpose: Lung nodule segmentation, i.e., the algorithmic delineation of the lung nodule surface, is a fundamental component of computational nodule analysis pipelines. We propose a new method for segmentation that is a machine learning based extension of current approaches, using labeled image examples to improve its accuracy. Approach: We introduce an extension of the standard level set image segmentation method where the velocity function is learned from data via machine learning regression methods, rather than a priori designed. Instead, the method employs a set of features to learn a veloc…

使用SAM和迁移学习进行肺结节高级分割与分类以实现肺癌早期检测

Advanced Lung Nodule Segmentation and Classification for Early Detection of Lung Cancer using SAM and Transfer Learning

本文提出将SAM与迁移学习结合，利用边界框提示和视觉Transformer实现肺结节高精度分割与分类，在CT数据上取得DSC 97.08%、IoU 95.6%和分类准确率96.71%，验证了其在肺癌早期检测中的有效性。

Extracting and Leveraging Nodule Features with Lung Inpainting for Local Feature Augmentation

Chest X-ray (CXR) is the most common examination for fast detection of pulmonary abnormalities. Recently, automated algorithms have been developed to classify multiple diseases and abnormalities in CXR scans. However, because of the limited availability of scans containing nodules and the subtle properties of nodules in CXRs, state-of-the-art methods do not perform well on nodule classification. To create additional data for the training process, standard augmentation techniques are applied. However, the variance introduced by these methods are limited as the images are typically modified glob…

Multi-Task Lung Nodule Detection in Chest Radiographs with a Dual Head Network

Lung nodules can be an alarming precursor to potential lung cancer. Missed nodule detections during chest radiograph analysis remains a common challenge among thoracic radiologists. In this work, we present a multi-task lung nodule detection algorithm for chest radiograph analysis. Unlike past approaches, our algorithm predicts a global-level label indicating nodule presence along with local-level labels predicting nodule locations using a Dual Head Network (DHN). We demonstrate the favorable nodule detection performance that our multi-task formulation yields in comparison to conventional meth…

Primary Tumor Origin Classification of Lung Nodules in Spectral CT using Transfer Learning

Early detection of lung cancer has been proven to decrease mortality significantly. A recent development in computed tomography (CT), spectral CT, can potentially improve diagnostic accuracy, as it yields more information per scan than regular CT. However, the shear workload involved with analyzing a large number of scans drives the need for automated diagnosis methods. Therefore, we propose a detection and classification system for lung nodules in CT scans. Furthermore, we want to observe whether spectral images can increase classifier performance. For the detection of nodules we trained a VG…

AI-based software for lung nodule detection in chest X-rays -- Time for a second reader approach?

Objectives: To compare artificial intelligence (AI) as a second reader in detecting lung nodules on chest X-rays (CXR) versus radiologists of two binational institutions, and to evaluate AI performance when using two different modes: automated versus assisted (additional remote radiologist review). Methods: The CXR public database (n = 247) of the Japanese Society of Radiological Technology with various types and sizes of lung nodules was analyzed. Eight radiologists evaluated the CXR images with regard to the presence of lung nodules and nodule conspicuity. After radiologist review, the AI so…

X-ray Dissectography Improves Lung Nodule Detection

Although radiographs are the most frequently used worldwide due to their cost-effectiveness and widespread accessibility, the structural superposition along the x-ray paths often renders suspicious or concerning lung nodules difficult to detect. In this study, we apply "X-ray dissectography" to dissect lungs digitally from a few radiographic projections, suppress the interference of irrelevant structures, and improve lung nodule detectability. For this purpose, a collaborative detection network is designed to localize lung nodules in 2D dissected projections and 3D physical space. Our experime…

Integration of Convolutional Neural Networks for Pulmonary Nodule Malignancy Assessment in a Lung Cancer Classification Pipeline

The early identification of malignant pulmonary nodules is critical for better lung cancer prognosis and less invasive chemo or radio therapies. Nodule malignancy assessment done by radiologists is extremely useful for planning a preventive intervention but is, unfortunately, a complex, time-consuming and error-prone task. This explains the lack of large datasets containing radiologists malignancy characterization of nodules. In this article, we propose to assess nodule malignancy through 3D convolutional neural networks and to integrate it in an automated end-to-end existing pipeline of lung …

Accurate Lung Nodules Segmentation with Detailed Representation Transfer and Soft Mask Supervision

Accurate lung lesion segmentation from Computed Tomography (CT) images is crucial to the analysis and diagnosis of lung diseases such as COVID-19 and lung cancer. However, the smallness and variety of lung nodules and the lack of high-quality labeling make the accurate lung nodule segmentation difficult. To address these issues, we first introduce a novel segmentation mask named Soft Mask which has richer and more accurate edge details description and better visualization and develop a universal automatic Soft Mask annotation pipeline to deal with different datasets correspondingly. Then, a no…

No Surprises: Training Robust Lung Nodule Detection for Low-Dose CT Scans by Augmenting with Adversarial Attacks

Detecting malignant pulmonary nodules at an early stage can allow medical interventions which may increase the survival rate of lung cancer patients. Using computer vision techniques to detect nodules can improve the sensitivity and the speed of interpreting chest CT for lung cancer screening. Many studies have used CNNs to detect nodule candidates. Though such approaches have been shown to outperform the conventional image processing based methods regarding the detection accuracy, CNNs are also known to be limited to generalize on under-represented samples in the training set and prone to imp…

ProCAN: Progressive Growing Channel Attentive Non-Local Network for Lung Nodule Classification

Lung cancer classification in screening computed tomography (CT) scans is one of the most crucial tasks for early detection of this disease. Many lives can be saved if we are able to accurately classify malignant/cancerous lung nodules. Consequently, several deep learning based models have been proposed recently to classify lung nodules as malignant or benign. Nevertheless, the large variation in the size and heterogeneous appearance of the nodules makes this task an extremely challenging one. We propose a new Progressive Growing Channel Attentive Non-Local (ProCAN) network for lung nodule cla…

Lung Segmentation and Nodule Detection in Computed Tomography Scan using a Convolutional Neural Network Trained Adversarially using Turing Test Loss

Lung cancer is the most common form of cancer found worldwide with a high mortality rate. Early detection of pulmonary nodules by screening with a low-dose computed tomography (CT) scan is crucial for its effective clinical management. Nodules which are symptomatic of malignancy occupy about 0.0125 - 0.025\% of volume in a CT scan of a patient. Manual screening of all slices is a tedious task and presents a high risk of human errors. To tackle this problem we propose a computationally efficient two stage framework. In the first stage, a convolutional neural network (CNN) trained adversarially …

U-Det: A Modified U-Net architecture with bidirectional feature network for lung nodule segmentation

Early diagnosis and analysis of lung cancer involve a precise and efficient lung nodule segmentation in computed tomography (CT) images. However, the anonymous shapes, visual features, and surroundings of the nodule in the CT image pose a challenging problem to the robust segmentation of the lung nodules. This article proposes U-Det, a resource-efficient model architecture, which is an end to end deep learning approach to solve the task at hand. It incorporates a Bi-FPN (bidirectional feature network) between the encoder and decoder. Furthermore, it uses Mish activation function and class weig…

Transfer Learning by Cascaded Network to identify and classify lung nodules for cancer detection

Lung cancer is one of the most deadly diseases in the world. Detecting such tumors at an early stage can be a tedious task. Existing deep learning architecture for lung nodule identification used complex architecture with large number of parameters. This study developed a cascaded architecture which can accurately segment and classify the benign or malignant lung nodules on computed tomography (CT) images. The main contribution of this study is to introduce a segmentation network where the first stage trained on a public data set can help to recognize the images which included a nodule from an…

Identification of lung nodules CT scan using YOLOv5 based on convolution neural network

Purpose: The lung nodules localization in CT scan images is the most difficult task due to the complexity of the arbitrariness of shape, size, and texture of lung nodules. This is a challenge to be faced when coming to developing different solutions to improve detection systems. the deep learning approach showed promising results by using convolutional neural network (CNN), especially for image recognition and it's one of the most used algorithm in computer vision. Approach: we use (CNN) building blocks based on YOLOv5 (you only look once) to learn the features representations for nodule detec…

Reducing Annotation Need in Self-Explanatory Models for Lung Nodule Diagnosis

Feature-based self-explanatory methods explain their classification in terms of human-understandable features. In the medical imaging community, this semantic matching of clinical knowledge adds significantly to the trustworthiness of the AI. However, the cost of additional annotation of features remains a pressing issue. We address this problem by proposing cRedAnno, a data-/annotation-efficient self-explanatory approach for lung nodule diagnosis. cRedAnno considerably reduces the annotation need by introducing self-supervised contrastive learning to alleviate the burden of learning most para…

Improved Focus on Hard Samples for Lung Nodule Detection（面向肺结节检测的难样本聚焦增强方法）

Improved Focus on Hard Samples for Lung Nodule Detection

针对公开肺部数据集少、CT图像肺结节尤其是难样本检测瓶颈问题，提出引入可变形卷积和自步学习的改进检测网络，经LUNA16数据集实验验证有效且性能具竞争力。

End-to-end lung nodule detection framework with model-based feature projection block

This paper proposes novel end-to-end framework for detecting suspicious pulmonary nodules in chest CT scans. The method core idea is a new nodule segmentation architecture with a model-based feature projection block on three-dimensional convolutions. This block acts as a preliminary feature extractor for a two-dimensional U-Net-like convolutional network. Using the proposed approach along with an axial, coronal, and sagittal projection analysis makes it possible to abandon the widely used false positives reduction step. The proposed method achieves SOTA on LUNA2016 with 0.959 average sensitivi…

Learning Tumor Growth via Follow-Up Volume Prediction for Lung Nodules

Follow-up serves an important role in the management of pulmonary nodules for lung cancer. Imaging diagnostic guidelines with expert consensus have been made to help radiologists make clinical decision for each patient. However, tumor growth is such a complicated process that it is difficult to stratify high-risk nodules from low-risk ones based on morphologic characteristics. On the other hand, recent deep learning studies using convolutional neural networks (CNNs) to predict the malignancy score of nodules, only provides clinicians with black-box predictions. To this end, we propose a unifie…

Lung nodules segmentation from CT with DeepHealth toolkit

The accurate and consistent border segmentation plays an important role in the tumor volume estimation and its treatment in the field of Medical Image Segmentation. Globally, Lung cancer is one of the leading causes of death and the early detection of lung nodules is essential for the early cancer diagnosis and survival rate of patients. The goal of this study was to demonstrate the feasibility of Deephealth toolkit including PyECVL and PyEDDL libraries to precisely segment lung nodules. Experiments for lung nodules segmentation has been carried out on UniToChest using PyECVL and PyEDDL, for d…

Deep fusion of gray level co-occurrence matrices for lung nodule classification

Lung cancer is a severe menace to human health, due to which millions of people die because of late diagnoses of cancer; thus, it is vital to detect the disease as early as possible. The Computerized chest analysis Tomography of scan is assumed to be one of the efficient solutions for detecting and classifying lung nodules. The necessity of high accuracy of analyzing C.T. scan images of the lung is considered as one of the crucial challenges in detecting and classifying lung cancer. A new long-short-term-memory (LSTM) based deep fusion structure, is introduced, where, the texture features comp…

AWEU-Net: An Attention-Aware Weight Excitation U-Net for Lung Nodule Segmentation

Lung cancer is deadly cancer that causes millions of deaths every year around the world. Accurate lung nodule detection and segmentation in computed tomography (CT) images is the most important part of diagnosing lung cancer in the early stage. Most of the existing systems are semi-automated and need to manually select the lung and nodules regions to perform the segmentation task. To address these challenges, we proposed a fully automated end-to-end lung nodule detection and segmentation system based on a deep learning approach. In this paper, we used Optimized Faster R-CNN; a state-of-the-art…

评估内存高效医学图像生成的效用：一项关于肺结节分割的研究

Evaluating Utility of Memory Efficient Medical Image Generation: A Study on Lung Nodule Segmentation

提出一种内存高效的逐块DDPM生成带肺结节分割的合成CT图像，实验表明仅用合成数据训练或用于增强真实数据均能提升分割性能，有效缓解医学影像数据稀缺问题。

Dual Skip Connections Minimize the False Positive Rate of Lung Nodule Detection in CT images

Pulmonary cancer is one of the most commonly diagnosed and fatal cancers and is often diagnosed by incidental findings on computed tomography. Automated pulmonary nodule detection is an essential part of computer-aided diagnosis, which is still facing great challenges and difficulties to quickly and accurately locate the exact nodules' positions. This paper proposes a dual skip connection upsampling strategy based on Dual Path network in a U-Net structure generating multiscale feature maps, which aims to minimize the ratio of false positives and maximize the sensitivity for lesion detection of…

A Radiogenomics Pipeline for Lung Nodules Segmentation and Prediction of EGFR Mutation Status from CT Scans

Lung cancer is a leading cause of death worldwide. Early-stage detection of lung cancer is essential for a more favorable prognosis. Radiogenomics is an emerging discipline that combines medical imaging and genomics features for modeling patient outcomes non-invasively. This study presents a radiogenomics pipeline that has: 1) a novel mixed architecture (RA-Seg) to segment lung cancer through attention and recurrent blocks; and 2) deep feature classifiers to distinguish Epidermal Growth Factor Receptor (EGFR) mutation status. We evaluate the proposed algorithm on multiple public datasets to as…

Lung-CADex：胸CT图像中肺结节的全自动零样本检测与分类

Lung-CADex: Fully automatic Zero-Shot Detection and Classification of Lung Nodules in Thoracic CT Images

本文提出Lung-CADex框架，利用MedSAM和CLIP实现肺结节零样本检测（CADe），并通过放射组学特征对比学习实现良恶性分类（CADx），在LIDC和LUNGx数据集上灵敏度达0.86，优于全监督方法。

Faithful learning with sure data for lung nodule diagnosis

Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First, benign-malignant discrimination is often assessed by human observers without pathologic diagnoses at the nodule level. We termed these data as "unsure data". Second, a classifier does not necessarily acquire reliable nodule features for stable learning and robust prediction with patch-level labels during learning. In this study, we construct a sure dataset with patholo…

基于深度学习的通道挤压U型结构用于肺结节检测与分割

Deep Learning-Based Channel Squeeze U-Structure for Lung Nodule Detection and Segmentation

本文提出一种基于深度学习的通道挤压U型结构，通过浅层信息处理、通道残差结构和通道挤压整合模块，在LIDC数据集上提升了肺结节检测与分割的精度与鲁棒性，助力早期肺癌诊断。

使用 VGG16 算法对 CT 扫描图像中的肺癌进行分类

Using VGG16 Algorithms for classification of lung cancer in CT scans Image

本文提出使用 VGG16 深度学习算法对 CT 扫描图像中的肺结节进行恶性、良性和健康分类，实现了 92.08% 的灵敏度、91% 的准确率和 93% 的 AUC。

Two-Stage Convolutional Neural Network Architecture for Lung Nodule Detection

Early detection of lung cancer is an effective way to improve the survival rate of patients. It is a critical step to have accurate detection of lung nodules in computed tomography (CT) images for the diagnosis of lung cancer. However, due to the heterogeneity of the lung nodules and the complexity of the surrounding environment, robust nodule detection has been a challenging task. In this study, we propose a two-stage convolutional neural network (TSCNN) architecture for lung nodule detection. The CNN architecture in the first stage is based on the improved UNet segmentation network to establ…

Enhancing Cancer Prediction in Challenging Screen-Detected Incident Lung Nodules Using Time-Series Deep Learning

Lung cancer is the leading cause of cancer-related mortality worldwide. Lung cancer screening (LCS) using annual low-dose computed tomography (CT) scanning has been proven to significantly reduce lung cancer mortality by detecting cancerous lung nodules at an earlier stage. Improving risk stratification of malignancy risk in lung nodules can be enhanced using machine/deep learning algorithms. However most existing algorithms: a) have primarily assessed single time-point CT data alone thereby failing to utilize the inherent advantages contained within longitudinal imaging datasets; b) have not …

使用残差编码器-解码器网络从胸部 X 线图像进行全分辨率肺结节分割

Full-resolution Lung Nodule Segmentation from Chest X-ray Images using Residual Encoder-Decoder Networks

本文提出处理全分辨率 CXR 的残差编码器-解码器及三连续 epoch 自集成模型，用于肺结节定位，并在 JSRT 与外部数据集上验证了高精度、快速推理和良好泛化性。

A multiscale Laplacian of Gaussian (LoG) filtering approach to pulmonary nodule detection from whole-lung CT scans

Candidate generation, the first stage for most computer aided detection (CAD) systems, rapidly scans the entire image data for any possible abnormality locations, while the subsequent stages of the CAD system refine the candidates list to determine the most probable or significant of these candidates. The candidate generator creates a list of the locations and provides a size estimate for each candidate. A multiscale scale-normalized Laplacian of Gaussian (LoG) filtering method for detecting pulmonary nodules in whole-lung CT scans, presented in this paper, achieves a high sensitivity for both…

Interpretative Computer-aided Lung Cancer Diagnosis: from Radiology Analysis to Malignancy Evaluation

Background and Objective:Computer-aided diagnosis (CAD) systems promote diagnosis effectiveness and alleviate pressure of radiologists. A CAD system for lung cancer diagnosis includes nodule candidate detection and nodule malignancy evaluation. Recently, deep learning-based pulmonary nodule detection has reached satisfactory performance ready for clinical application. However, deep learning-based nodule malignancy evaluation depends on heuristic inference from low-dose computed tomography volume to malignant probability, which lacks clinical cognition. Methods:In this paper, we propose a joint…

Learning from Ambiguous Labels for Lung Nodule Malignancy Prediction

Lung nodule malignancy prediction is an essential step in the early diagnosis of lung cancer. Besides the difficulties commonly discussed, the challenges of this task also come from the ambiguous labels provided by annotators, since deep learning models may learn, even amplify, the bias embedded in them. In this paper, we propose a multi-view "divide-and-rule" (MV-DAR) model to learn from both reliable and ambiguous annotations for lung nodule malignancy prediction. According to the consistency and reliability of their annotations, we divide nodules into three sets: a consistent and reliable s…

使用 Swin Transformer 检测肺结节的高效方法

An Efficient Approach to Detecting Lung Nodules Using Swin Transformer

针对肺结节检测效率不足的问题，提出基于2D CT切片与tiny版Swin Transformer结合Feature Pyramid Network和Transfer Learning的高效检测方法，实现94.7% mAP和94.9% mAR，在小结节检测上超越现有方法。

CAE-Transformer: Transformer-based Model to Predict Invasiveness of Lung Adenocarcinoma Subsolid Nodules from Non-thin Section 3D CT Scans

Lung cancer is the leading cause of mortality from cancer worldwide and has various histologic types, among which Lung Adenocarcinoma (LUAC) has recently been the most prevalent one. The current approach to determine the invasiveness of LUACs is surgical resection, which is not a viable solution to fight lung cancer in a timely fashion. An alternative approach is to analyze chest Computed Tomography (CT) scans. The radiologists' analysis based on CT images, however, is subjective and might result in a low accuracy. In this paper, a transformer-based framework, referred to as the "CAE-Transform…

Swin-Tempo：使用Swin Transformer增强UNet将CT扫描中的肺结节检测视为视频序列的时间感知方法

Swin-Tempo: Temporal-Aware Lung Nodule Detection in CT Scans as Video Sequences Using Swin Transformer-Enhanced UNet

针对CT肺结节检测中计算复杂与误诊率高的问题，提出融合CNN与视觉Transformer的Swin-Tempo模型，将3D CT视为视频序列，在Luna16数据集上以少参数实现97.84%灵敏度和96.0%CPM。

Siamese Encoder-based Spatial-Temporal Mixer for Growth Trend Prediction of Lung Nodules on CT Scans

In the management of lung nodules, we are desirable to predict nodule evolution in terms of its diameter variation on Computed Tomography (CT) scans and then provide a follow-up recommendation according to the predicted result of the growing trend of the nodule. In order to improve the performance of growth trend prediction for lung nodules, it is vital to compare the changes of the same nodule in consecutive CT scans. Motivated by this, we screened out 4,666 subjects with more than two consecutive CT scans from the National Lung Screening Trial (NLST) dataset to organize a temporal dataset ca…

CIRDataset: A large-scale Dataset for Clinically-Interpretable lung nodule Radiomics and malignancy prediction

Spiculations/lobulations, sharp/curved spikes on the surface of lung nodules, are good predictors of lung cancer malignancy and hence, are routinely assessed and reported by radiologists as part of the standardized Lung-RADS clinical scoring criteria. Given the 3D geometry of the nodule and 2D slice-by-slice assessment by radiologists, manual spiculation/lobulation annotation is a tedious task and thus no public datasets exist to date for probing the importance of these clinically-reported features in the SOTA malignancy prediction algorithms. As part of this paper, we release a large-scale Cl…

Image Synthesis with Disentangled Attributes for Chest X-Ray Nodule Augmentation and Detection

Lung nodule detection in chest X-ray (CXR) images is common to early screening of lung cancers. Deep-learning-based Computer-Assisted Diagnosis (CAD) systems can support radiologists for nodule screening in CXR. However, it requires large-scale and diverse medical data with high-quality annotations to train such robust and accurate CADs. To alleviate the limited availability of such datasets, lung nodule synthesis methods are proposed for the sake of data augmentation. Nevertheless, previous methods lack the ability to generate nodules that are realistic with the size attribute desired by the …

CPLOYO：一种具有多尺度特征融合与非线性特征学习的肺结节检测模型

CPLOYO: A Pulmonary Nodule Detection Model with Multi-Scale Feature Fusion and Nonlinear Feature Learning

本文面向多类型肺结节高灵敏检测，改进 YOLOv8，融合 C2f_RepViTCAMF、MSCAF 与 KAN，以增强小目标、多尺度及非线性特征学习，并在 LUNA16 上优于多种主流模型。

Volumetric Lung Nodule Segmentation using Adaptive ROI with Multi-View Residual Learning

Accurate quantification of pulmonary nodules can greatly assist the early diagnosis of lung cancer, which can enhance patient survival possibilities. A number of nodule segmentation techniques have been proposed, however, all of the existing techniques rely on radiologist 3-D volume of interest (VOI) input or use the constant region of interest (ROI) and only investigate the presence of nodule voxels within the given VOI. Such approaches restrain the solutions to investigate the nodule presence outside the given VOI and also include the redundant structures into VOI, which may lead to inaccura…

Uncertainty-Guided Lung Nodule Segmentation with Feature-Aware Attention

Since radiologists have different training and clinical experiences, they may provide various segmentation annotations for a lung nodule. Conventional studies choose a single annotation as the learning target by default, but they waste valuable information of consensus or disagreements ingrained in the multiple annotations. This paper proposes an Uncertainty-Guided Segmentation Network (UGS-Net), which learns the rich visual features from the regions that may cause segmentation uncertainty and contributes to a better segmentation result. With an Uncertainty-Aware Module, this network can provi…

Dual-branch residual network for lung nodule segmentation

An accurate segmentation of lung nodules in computed tomography (CT) images is critical to lung cancer analysis and diagnosis. However, due to the variety of lung nodules and the similarity of visual characteristics between nodules and their surroundings, a robust segmentation of nodules becomes a challenging problem. In this study, we propose the Dual-branch Residual Network (DB-ResNet) which is a data-driven model. Our approach integrates two new schemes to improve the generalization capability of the model: 1) the proposed model can simultaneously capture multi-view and multi-scale features…

Effect of Input Size on the Classification of Lung Nodules Using Convolutional Neural Networks

Recent studies have shown that lung cancer screening using annual low-dose computed tomography (CT) reduces lung cancer mortality by 20% compared to traditional chest radiography. Therefore, CT lung screening has started to be used widely all across the world. However, analyzing these images is a serious burden for radiologists. The number of slices in a CT scan can be up to 600. Therefore, computer-aided-detection (CAD) systems are very important for faster and more accurate assessment of the data. In this study, we proposed a framework that analyzes CT lung screenings using convolutional neu…

胸部X光片上的结节检测与生成：NODE21挑战赛

Nodule detection and generation on chest X-rays: NODE21 Challenge

本文总结了NODE21挑战赛，该挑战旨在通过检测和生成两个赛道，评估胸部X光片中的肺结节检测系统及利用结节生成算法增强数据来提升检测性能的方法，并验证了合成数据对检测算法的积极影响。

基于跨时空病理信息的肺结节数据集

A Cross Spatio-Temporal Pathology-based Lung Nodule Dataset

针对现有肺结节数据集忽略跨时空特征的问题，构建了包含109名患者328个CT序列和362个标注结节的跨时空病理数据集，以推动CAD方法及精准医学发展。

Detection, growth quantification and malignancy prediction of pulmonary nodules using deep convolutional networks in follow-up CT scans

We address the problem of supporting radiologists in the longitudinal management of lung cancer. Therefore, we proposed a deep learning pipeline, composed of four stages that completely automatized from the detection of nodules to the classification of cancer, through the detection of growth in the nodules. In addition, the pipeline integrated a novel approach for nodule growth detection, which relied on a recent hierarchical probabilistic U-Net adapted to report uncertainty estimates. Also, a second novel method was introduced for lung cancer nodule classification, integrating into a two stre…

Attention-Enhanced Cross-Task Network for Analysing Multiple Attributes of Lung Nodules in CT

Accurate characterisation of visual attributes such as spiculation, lobulation, and calcification of lung nodules is critical in cancer management. The characterisation of these attributes is often subjective, which may lead to high inter- and intra-observer variability. Furthermore, lung nodules are often heterogeneous in the cross-sectional image slices of a 3D volume. Current state-of-the-art methods that score multiple attributes rely on deep learning-based multi-task learning (MTL) schemes. These methods, however, extract shared visual features across attributes and then examine each attr…

Debiasing pipeline improves deep learning model generalization for X-ray based lung nodule detection

Lung cancer is the leading cause of cancer death worldwide and a good prognosis depends on early diagnosis. Unfortunately, screening programs for the early diagnosis of lung cancer are uncommon. This is in-part due to the at-risk groups being located in rural areas far from medical facilities. Reaching these populations would require a scaled approach that combines mobility, low cost, speed, accuracy, and privacy. We can resolve these issues by combining the chest X-ray imaging mode with a federated deep-learning approach, provided that the federated model is trained on homogenous data to ensu…

cRedAnno+: Annotation Exploitation in Self-Explanatory Lung Nodule Diagnosis

Recently, attempts have been made to reduce annotation requirements in feature-based self-explanatory models for lung nodule diagnosis. As a representative, cRedAnno achieves competitive performance with considerably reduced annotation needs by introducing self-supervised contrastive learning to do unsupervised feature extraction. However, it exhibits unstable performance under scarce annotation conditions. To improve the accuracy and robustness of cRedAnno, we propose an annotation exploitation mechanism by conducting semi-supervised active learning with sparse seeding and training quenching …

A new semi-supervised self-training method for lung cancer prediction

Background and Objective: Early detection of lung cancer is crucial as it has high mortality rate with patients commonly present with the disease at stage 3 and above. There are only relatively few methods that simultaneously detect and classify nodules from computed tomography (CT) scans. Furthermore, very few studies have used semi-supervised learning for lung cancer prediction. This study presents a complete end-to-end scheme to detect and classify lung nodules using the state-of-the-art Self-training with Noisy Student method on a comprehensive CT lung screening dataset of around 4,000 CT …

Self-DenseMobileNet：一种使用 Self-ONN 和基于 Stacking 的元分类器的肺结节分类鲁棒框架

Self-DenseMobileNet: A Robust Framework for Lung Nodule Classification using Self-ONN and Stacking-based Meta-Classifier

本研究提出 Self-DenseMobileNet 框架，结合图像增强与 Stacking 元分类器，在胸部 X 光片肺结节分类中实现 99.28% 内部准确率和 89.40% 外部泛化准确率。