跟踪癌症对微管动态不稳定性的影响
Tracking the Effects of Cancer on Microtubule Dynamic Instability
摘要：
细胞骨架的动态不稳定性是许多重要细胞过程的基础。在神经元中，它被认为在信息处理和突触连接的建立中发挥作用。正是从这种神经元间的连接，大脑的大规模组织和功能最终出现。虽然大脑网络以上的细胞规模已被广泛研究与医学成像，还没有研究检查的动态架构subserving这些网络的组件，他们的功能的贡献。同时在分子和全脑尺度的功能成像可能会产生更全面的知识，这意味着。最近开发的微管动力学的非线性模型的基础上的统计分析程序，提出验证各种微管相关蛋白质的活动和功能连接之间的时空关系的预测。脑癌对功能连接性和瘤周复杂性的已知影响可作为在具有特别高和低复杂性的感兴趣区域中对这些现象进行比较研究的基础。
英文摘要：
Dynamic instability in the cytoskeleton underlies a great many vital cellular processes. In neurons, it is thought to play a role in information processing and the establishment of synaptic connections. It is from this interneuronal connectivity that the large-scale organization and function of the brain ultimately emerges. While brain networks above the cellular scale have been extensively investigated with medical imaging, no research has yet examined the contribution of the dynamic architecture subserving the components of these networks to their functionality. Simultaneous functional imaging at molecular and whole-brain scales may yield more comprehensive knowledge of this entailment. Procedures of statistical analysis based on a recently developed nonlinear model of microtubule dynamics are proposed to verify predictions about the spatiotemporal relationships between various microtubule-associated protein activities and functional connectivity. Known effects of brain cancer on functional connectivity and peritumoral complexity serve as the basis for a comparative study of these phenomena in regions of interest with particularly high and low complexity.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
