长弹性管蠕动过程中的泵送模式和做功
Pumping Patterns and Work Done during Peristalsis in Finite-length Elastic Tubes
摘要：
球囊扩张导管通常用于量化管状器官中蠕动活动的生理状态，并评价其推进液体的能力，这对健康人体功能很重要。为了充分理解该系统的行为，我们分析了孤立蠕动波对两端封闭的充满流体的弹性管的影响。一个降阶模型，预测所产生的管壁变形，流速和压力变化。这个简化的模型进行了比较详细的流体-结构三维浸没边界模拟蠕动泵在管壁的超弹性材料。我们的一维模型在层流条件下也显示了在三维模拟中观察到的主要动力学。使用1D模型，几个泵送制度进行了研究，并提出了一个制度地图的形式，总结了系统的响应范围内的生理条件。最后，定义并量化了在此配置中蠕动事件期间完成的工作量。弹性能量的变化和泵送过程中所做的工作被发现有一个独特的签名为每个政权。应用1D模型的扩展来增强设备收集的患者数据，并找到典型食管蠕动波所做的工作。系统行为的详细表征有助于更好地解释从扩张导管获得的临床数据。此外，可以量化食管的泵送能力，用于疾病组之间的比较研究。
英文摘要：
Balloon dilation catheters are often used to quantify the physiological state of peristaltic activity in tubular organs and comment on their ability to propel fluid which is important for healthy human function. To fully understand this system's behavior, we analyzed the effect of a solitary peristaltic wave on a fluid-filled elastic tube with closed ends. A reduced order model that predicts the resulting tube wall deformations, flow velocities and pressure variations is presented. This simplified model is compared with detailed fluid-structure 3D immersed boundary simulations of peristaltic pumping in tube walls made of hyperelastic material. The major dynamics observed in the 3D simulations were also displayed by our 1D model under laminar flow conditions. Using the 1D model, several pumping regimes were investigated and presented in the form of a regime map that summarizes the system's response for a range of physiological conditions. Finally, the amount of work done during a peristaltic event in this configuration was defined and quantified. The variation of elastic energy and work done during pumping was found to have a unique signature for each regime. An extension of the 1D model is applied to enhance patient data collected by the device and find the work done for a typical esophageal peristaltic wave. This detailed characterization of the system's behavior aids in better interpreting the clinical data obtained from dilation catheters. Additionally, the pumping capacity of the esophagus can be quantified for comparative studies between disease groups.
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