管状心脏血细胞的动态抽吸
On the dynamic suction pumping of blood cells in tubular hearts
摘要：
在胚胎发育的妊娠后第三周左右，人类的心脏仅由一个无瓣管组成，不像发育完全的成人心脏是多腔的。在发育的这个阶段，心脏瓣膜还没有形成，因此通过心脏的血液净流量必须由不同的机制驱动。假设有两种可能的机制在此阶段驱动血流- Liebau泵送（动态抽吸泵送或无阀泵送）和蠕动泵送。本文采用浸入边界法和自适应网格加密技术（IBAMR）数值模拟了红细胞压积对无瓣绕流的影响。同时考虑了离心泵和动态抽吸泵。在动态抽吸泵送的情况下，心脏和循环系统被简化为连接到相对刚性的跑道的柔性管。对于一些沃默斯利数（Wo）制度，有显着的净流量周围的赛道。我们发现柔性血细胞的添加不会显著影响Wo $\leq$ 10的管内的流速。另一方面，对于所考虑的所有Wo和所有红细胞压积，红细胞压积始终驱动赛道周围的血液。
英文摘要：
Around the third week after gestation in embryonic development, the human heart consists only of a valvless tube, unlike a fully developed adult heart, which is multi-chambered. At this stage in development, the heart valves have not formed and so net flow of blood through the heart must be driven by a different mechanism. It is hypothesized that there are two possible mechanisms that drive blood flow at this stage - Liebau pumping (dynamic suction pumping or valveless pumping) and peristaltic pumping. We implement the immersed boundary method with adaptive mesh refinement (IBAMR) to numerically study the effect of hematocrit on the circulation around a valveless. Both peristalsis and dynamic suction pumping are considered. In the case of dynamic suction pumping, the heart and circulatory system is simplified as a flexible tube attached to a relatively rigid racetrack. For some Womersley number (Wo) regimes, there is significant net flow around the racetrack. We find that the addition of flexible blood cells does not significantly affect flow rates within the tube for Wo $\leq$ 10. On the other hand, peristalsis consistently drives blood around the racetrack for all Wo and for all hematocrit considered.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
