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arXiv 1908.059192019-08-16cond-mat.softphysics.bio-phq-bio.BM

$θ$-curves in proteins

Pawel Dabrowski-Tumanski, Dimos Goundaroulis, Andrzej Stasiak, Joanna I. Sulkowska

英文摘要：

Apart from the knots formed by the main-chain, the proteins can form numerous topological structures, when included the covalent and ion-mediated interactions. In this work, we define the protein non-trivial $θ$-curves and identify 7 different topologies in all structures known up to date. We study the correlation of the motif with the function and organism of origin, and pointing the similarity with main-chain knots, we show that some motifs may indeed be functional. We also analyze the folding and bridge-induced stability of an exemplary protein with $θ$-curve motif and provide a catalogue of possible $θ$-curves in proteins.

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