Diffusive Mobile MC with Absorbing Receivers: Stochastic Analysis and Applications
Trang Ngoc Cao, Arman Ahmadzadeh, Vahid Jamali, Wayan Wicke, Phee Lep Yeoh, Jamie Evans, Robert Schober
备注：
30 pages, 9 figures, this paper has been submitted to IEEE for possible publication and presented in part at IEEE ICC 2019. arXiv admin note: text overlap with arXiv:1811.00417
This paper presents a stochastic analysis of the time-variant channel impulse response (CIR) of a three dimensional diffusive mobile molecular communication (MC) system where the transmitter, the absorbing receiver, and the molecules can freely diffuse. In our analysis, we derive the mean, variance, probability density function (PDF), and cumulative distribution function (CDF) of the CIR. We also derive the PDF and CDF of the probability p that a released molecule is absorbed at the receiver during a given time period. The obtained analytical results are employed for the design of drug delivery and MC systems with imperfect channel state information. For the first application, we exploit the mean and variance of the CIR to optimize a controlled-release drug delivery system employing a mobile drug carrier. We evaluate the performance of the proposed release design based on the PDF and CDF of the CIR. We demonstrate significant savings in the amount of released drugs compared to a constant-release scheme and reveal the necessity of accounting for the drug-carrier's mobility to ensure reliable drug delivery. For the second application, we exploit the PDF of the distance between the mobile transceivers and the CDF of p to optimize three design parameters of an MC system employing on-off keying modulation and threshold detection. Specifically, we optimize the detection threshold at the receiver, the release profile at the transmitter, and the time duration of a bit frame. We show that the proposed optimal designs can significantly improve the system performance in terms of the bit error rate and the efficiency of molecule usage.
In this letter, we consider a 3D molecular communication via diffusion system (MCvDS) with a single point transmitter and multiple fully-absorbing spherical receivers whose centers are distributed as a Poisson point process (PPP) in the medium. We derive the probability that a transmitted molecule hits any of the receivers within time t. We consider both degradable and non-degradable molecules. We verify the analysis using particle-based simulation. The framework can be used for various applications, e.g., to derive event detection probability for systems where the IMs are transmitted to conve…
This letter introduces an analytical model that gives the asymptotic cumulative number of molecules absorbed by spherical receivers in a diffusive multiple-input multiple-output (MIMO) molecular communication (MC) system with pointwise transmitters. In the proposed model, the reciprocal effect among the fully absorbing (FA) receivers is described by using the concept of fictitious pointwise negative source of molecules, the best position of which for each spherical receiver being defined by its absorption barycenter. We show that there is an agreement between the proposed asymptotic model and …
Exact analytical channel models for molecular communication via diffusion (MCvD) systems involving multiple fully absorbing receivers (FARs) in a three-dimensional (3- D) medium are hard to obtain due to the mathematical intractability of corresponding diffusion equations. This work, therefore, consider an MCvD system with two spherical FARs in a 3-D diffusion-limited medium and develop several insights using an approximate analytical expression for the hitting probability of information molecule (IM). Further, based on the hitting probability, a novel approximate closed-form analytical expres…
We consider a molecular communication system comprised of a transmitter, an absorbing receiver, and an interference source. Assuming amplitude modulation, we analyze the dependence of the bit error rate (BER) on the detection interval, which is the time within one transmission symbol interval during which the receiver is active to absorb and detect the number of information-carrying molecules. We then propose efficient algorithms to determine the optimal detection interval that minimizes the BER of the molecular communication system assuming no inter-symbol interference (ISI). Simulation and n…
Molecular communication (MC) can enable the transfer of information between nanomachines using molecules as the information carrier. In MC systems, multiple receiver nanomachines often co-exist in the same communication channel to serve common or different purposes. However, the analytical channel model for a system with multiple fully absorbing receivers (FARs) does not exist in the literature, which is significantly different from the single FAR system due to the mutual influence of FARs. The analytical channel model is essential in analyzing systems with multiple FARs, including MIMO, SIMO,…
The performance of molecular communication is significantly impacted by the reception process of the messenger molecules. The receptors' size and density, however, have yet to be investigated. In this letter, we analyze the effect of receptor density and size on the signal reception of an absorbing receiver with receptors. The results show that, when the total receptor area is the same, better hitting probability is achieved by using a higher number of relatively small receptors. In addition, deploying receptors, which cover a small percentage of the receiver surface, is able to create an effe…
Within the domain of molecular communications, researchers mimic the techniques in nature to come up with alternative communication methods for collaborating nanomachines. This work investigates the channel transfer function for molecular communication via diffusion. In nature, information-carrying molecules are generally absorbed by the target node via receptors. Using the concentration function, without considering the absorption process, as the channel transfer function implicitly assumes that the receiver node does not affect the system. In this letter, we propose a solid analytical formul…
The simulation of diffusion-based molecular communication systems with absorbing receivers often requires a high computational complexity to produce accurate results. In this work, a new a priori Monte Carlo (APMC) algorithm is proposed to precisely simulate the molecules absorbed at a spherical receiver when the simulation time step length is relatively large. This algorithm addresses the limitations of the current refined Monte Carlo (RMC) algorithm, since the RMC algorithm provides accurate simulation only for a relatively small time step length. The APMC algorithm is demonstrated to achiev…
In this paper an analytical model is introduced to describe the impulse response of the diffusive channel between a pointwise transmitter and a given fully-absorbing (FA) receiver in a molecular communication (MC) system. The presence of neighbouring FA nanomachines in the environment is taken into account by describing them as sources of negative molecules. The channel impulse responses of all the receivers are linked in a system of integral equations. The solution of the system with two receivers is obtained analytically. For a higher number of receivers the system of integral equations is s…
In this paper, we perform receiver design for a diffusive molecular communication environment. Our model includes flow in any direction, sources of information molecules in addition to the transmitter, and enzymes in the propagation environment to mitigate intersymbol interference. We characterize the mutual information between receiver observations to show how often independent observations can be made. We derive the maximum likelihood sequence detector to provide a lower bound on the bit error probability. We propose the family of weighted sum detectors for more practical implementation and …
Molecular communication is a promising solution to enable intra-body communications among nanomachines. However, malicious and non-cooperative receivers can degrade the performance, compromising these systems' security. Analyzing the communication and security performance of these systems requires accurate channel models. However, such models are not present in the literature. In this work, we develop an analytical framework to derive the hitting probability of a molecule on a fully absorbing receiver (FAR) in the presence of other FARs, which can be either be cooperative or malicious. We firs…
This paper investigates the estimation of different parameters, e.g., propagation distance and flow velocity, by utilizing two fully-absorbing receivers (RXs) in a one-dimensional (1D) environment. The time-varying number of absorbed molecules at each RX and the number of absorbed molecules in a time interval as time approaches infinity are derived. Noisy molecules in this environment, that are released by sources in addition to the transmitter, are also considered. A novel estimation method, namely difference estimation (DE), is proposed to eliminate the effect of noise by using the differenc…
This paper studies the mitigation of intersymbol interference in a diffusive molecular communication system using enzymes that freely diffuse in the propagation environment. The enzymes form reaction intermediates with information molecules and then degrade them so that they cannot interfere with future transmissions. A lower bound expression on the expected number of molecules measured at the receiver is derived. A simple binary receiver detection scheme is proposed where the number of observed molecules is sampled at the time when the maximum number of molecules is expected. Insight is also …
This paper studies the problem of receiver modeling in molecular communication systems. We consider the diffusive molecular communication channel between a transmitter nano-machine and a receiver nano-machine in a fluid environment. The information molecules released by the transmitter nano-machine into the environment can degrade in the channel via a first-order degradation reaction and those that reach the receiver nano-machine can participate in a reversible bimolecular reaction with receiver receptor proteins. Thereby, we distinguish between two scenarios. In the first scenario, we assume …
In this paper, we study the performance of detectors in a diffusive molecular communication environment where steady uniform flow is present. We derive the expected number of information molecules to be observed in a passive spherical receiver, and determine the impact of flow on the assumption that the concentration of molecules throughout the receiver is uniform. Simulation results show the impact of advection on detector performance as a function of the flow's magnitude and direction. We highlight that there are disruptive flows, i.e., flows that are not in the direction of information tran…
This letter introduces a formalism for modeling time-variant channels for diffusive molecular communication systems. In particular, we consider a fluid environment where one transmitter nano-machine and one receiver nano-machine are subjected to Brownian motion in addition to the diffusive motion of the information molecules used for communication. Due to the stochastic movements of the transmitter and receiver nano-machines, the statistics of the channel impulse response change over time. We show that the time-variant behaviour of the channel can be accurately captured by appropriately modify…
In this paper, we present an analytical model for a diffusive molecular communication (MC) system with a reversible adsorption receiver in a fluid environment. The time-varying spatial distribution of the information molecules under the reversible adsorption and desorption reaction at the surface of a bio-receiver is analytically characterized. Based on the spatial distribution, we derive the number of newly-adsorbed information molecules expected in any time duration. Importantly, we present a simulation framework for the proposed model that accounts for the diffusion and reversible reaction.…
In this paper, we consider a diffusive mobile molecular communication (MC) system consisting of a pair of mobile transmitter and receiver nano-machines suspended in a fluid medium, where we model the mobility of the nano-machines by Brownian motion. The transmitter and receiver nano-machines exchange information via diffusive signaling molecules. Due to the random movements of the transmitter and receiver nano-machines, the statistics of the channel impulse response (CIR) change over time. We introduce a statistical framework for characterization of the impulse response of time-variant MC chan…
In this paper, we develop a mathematical framework for modeling the time-variant stochastic channels of diffusive mobile MC systems. In particular, we consider a diffusive mobile MC system consisting of a pair of transmitter and receiver nano-machines suspended in a fluid medium with a uniform bulk flow, where we assume that either the transmitter, or the receiver, or both are mobile and we model the mobility by Brownian motion. The transmitter and receiver nano-machines exchange information via diffusive signaling molecules. Due to the random movements of the transmitter and receiver nano-mac…
This work presents a performance analysis for diffusive molecular communication with mobile transmit and receive nanomachines. To begin with, the optimal test is obtained for symbol detection at the receiver nanomachine. Subsequently, closed-form expressions are derived for the probabilities of detection and false alarm, probability of error, and capacity considering also aberrations such as multi-source interference, inter-symbol interference, and counting errors. Simulation results are presented to corroborate the theoretical results derived and also, to yield various insights into the perfo…
Motivated by the numerous healthcare applications of molecular communication (MC) inside blood vessels, this work considers relay/cooperative nanomachine (CN)-assisted mobile MC between a source nanomachine (SN) and a destination nanomachine (DN) where each nanomachine is mobile in a flow-induced diffusive channel. Using the first hitting time model, the impact of an intermediate CN on the performance of the CN-assisted diffusive mobile MC system with fully absorbing receivers is analyzed in the presence of inter-symbol interference, multi-source interference, and counting errors. For this pur…
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In molecular communication (MC) systems, the \textit{expected} number of molecules observed at the receiver over time after the instantaneous release of molecules by the transmitter is referred to as the channel impulse response (CIR). Knowledge of the CIR is needed for the design of detection and equalization schemes. In this paper, we present a training-based CIR estimation framework for MC systems which aims at estimating the CIR based on the \textit{observed} number of molecules at the receiver due to emission of a \textit{sequence} of known numbers of molecules by the transmitter. Thereby…
Information delivery using chemical molecules is an integral part of biology at multiple distance scales and has attracted recent interest in bioengineering and communication. The collective signal strength at the receiver (i.e., the expected number of observed molecules inside the receiver), resulting from a large number of transmitters at random distances (e.g., due to mobility), can have a major impact on the reliability and efficiency of the molecular communication system. Modeling the collective signal from multiple diffusion sources can be computationally and analytically challenging. In…
This work considers the problem of flow-induced diffusive molecular communication under various mobility conditions such as (i) both transmitter (TX) and receiver (RX) nanomachines are mobile, (ii) TX is mobile and RX is fixed, and (iii) TX is fixed and RX is mobile. Closed-form expressions for the probability density function (PDF) of the first hitting time under the aforementioned mobile scenarios are derived, by characterizing the movement of the nanomachines and information molecules using Brownian motion with positive drift. The derived PDF expressions are validated through particle-based…
Diffusive molecular communications (DiMC) have recently gained attention as a candidate for nano- to micro- and macro-scale communications due to its simplicity and energy efficiency. As signal propagation is solely enabled by Brownian motion mechanics, DiMC faces severe inter-symbol interference (ISI), which limits reliable and high data-rate communications. Herein, recent literature on DiMC performance enhancement strategies is surveyed; key research directions are identified. Signaling design and associated design constraints are presented. Classical and novel transceiver designs are review…
Information delivery using chemical molecules is an integral part of biology at multiple distance scales and has attracted recent interest in bioengineering and communication theory. Potential applications include cooperative networks with a large number of simple devices that could be randomly located (e.g., due to mobility). This paper presents the first tractable analytical model for the collective signal strength due to randomly-placed transmitters in a three-dimensional (3D) large-scale molecular communication system, either with or without degradation in the propagation environment. Tran…
Recently, hybrid models have emerged that combine microscopic and mesoscopic regimes in a single stochastic reaction-diffusion simulation. Microscopic simulations track every individual molecule and are generally more accurate. Mesoscopic simulations partition the environment into subvolumes, track when molecules move between adjacent subvolumes, and are generally more computationally efficient. In this paper, we present the foundation of a multi-scale stochastic simulator from the perspective of molecular communication, for both mesoscopic and hybrid models, where we emphasize simulation accu…
This paper proposes a novel imperfect transmitter (TX) model, namely the membrane fusion (MF)-based TX, that adopts MF between a vesicle and the TX membrane to release molecules encapsulated within the vesicle. For the MF-based TX, the molecule release probability and the fraction of molecules released from the TX membrane are derived. Incorporating molecular degradation and a fully-absorbing receiver (RX), the channel impulse response (CIR) is derived for two scenarios: 1) Both TX and RX are static, and 2) both TX and RX are diffusion-based mobile. Moreover, a sequence of bits transmitted fro…
In this paper, we consider molecular communications in one-dimensional flow-induced diffusion channels with a perfectly absorbing receiver. In such channels, the random propagation delay until the molecules are absorbed follows an inverse Gaussian (IG) distribution and is referred to as first hitting time. Knowing the distribution for the difference of the first hitting times of two molecules is very important if the information is encoded by a limited set of molecules and the receiver exploits their arrival time and/or order. Hence, we propose a moment matching approximation by a normal inver…
