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arXiv 1908.00122physics.med-phphysics.bio-ph
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相关张量磁共振成像

Correlation Tensor Magnetic Resonance Imaging

Rafael Neto Henriques, Sune Nørhøj Jespersen, Noam Shemesh

摘要:

弥散峰度成像(DKI)是健康和疾病中微结构的敏感生物标志物。然而,DKI并不特定于任何微观结构特性,因为它可能来自几个不同的来源。Q空间轨迹编码已被提出用于从各向异性峰度解耦各向同性。尽管如此,该方法假设系统由多个高斯扩散分量组成。在这里,我们开发了一个更一般的框架,解决潜在的峰度来源。我们介绍了相关张量MRI(CTI)-一种利用双扩散编码(DDE)的多功能性的方法,能够明确地解耦各向同性和各向异性峰度分量从室内峰度效应所产生的限制扩散。此外,CTI提供了一个对房室内峰度潜在敏感的指标。CTI的理论基础,以及第一个概念验证的CTI离体实验在小鼠大脑中的16.4T的字段,提出。我们发现,各向异性和各向同性峰度可以解耦组织和自由水之间的大量部分体积效应的微观各向异性。我们的房室内峰度指数在白质和灰质组织中都表现出正值。然而,在不同的微环境中的模拟表明,我们目前的CTI协议估计房室内峰度是有限的高阶项,在这项研究中没有考虑。然后将CTI测量扩展到体内环境,并用于在9.4T下绘制健康大鼠大脑。这些体内CTI结果与我们的离体研究结果一致。虽然未来的研究仍然需要减轻高阶效应的房室内峰度指数,结果表明,CTI的各向异性和各向同性峰度贡献的更一般的估计已经成熟,为未来的研究。

英文摘要:

Diffusional Kurtosis Imaging (DKI) is a sensitive biomarker for microstructure in health and disease. However, DKI is not specific to any microstructural property since it may emerge from several different sources. Q-space trajectory encoding has been proposed for decoupling isotropic from anisotropic kurtosis. Still, this method assume that the system is comprised of multiple Gaussian diffusion components. Here, we develop a more general framework for resolving the underlying kurtosis sources. We introduce Correlation Tensor MRI (CTI) - an approach harnessing the versatility of double diffusion encoding (DDE) and capable of explicitly decoupling isotropic and anisotropic kurtosis components from intra-compartmental kurtosis effects arising from restricted diffusion. Additionally, CTI provides an index that is potentially sensitive to intra-compartmental kurtosis. The theoretical foundations of CTI, as well as the first proof-of-concept CTI ex vivo experiments in mouse brains at a field of 16.4T, are presented. We find that anisotropic and isotropic kurtosis can decouple microscopic anisotropy from substantial partial volume effects between tissue and free water. Our intra-compartmental kurtosis index exhibited positive values in both white and grey matter tissues. Simulations in different microenvironments show, however, that our current CTI protocol for estimating intra-compartmental kurtosis is limited by higher-order terms that were not considered in this study. CTI measurements were then extended to in vivo settings and used to map healthy rat brains at 9.4T. These in vivo CTI results were consistent with our ex vivo findings. Although future studies are still required to mitigate the higher-order effects on the intra-compartmental kurtosis index, results show that CTI's more general estimates of anisotropic and isotropic kurtosis contributions are already ripe for future studies.

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