轴突计算
Axonal Computations
摘要:
轴突在功能上将体树隔室与突触末梢连接起来。在结构和功能上的多样性,他们完成了一个核心的作用,在确定延迟和可靠性与神经元合奏通信。通过结合它们的主动和被动生物物理特性,它们确保了过多的生理计算。在这篇综述中,我们重新审视了生物物理学的产生和传播的电信号在轴突,它们复杂的相互作用,以及它们丰富的动态。我们进一步将轴突的计算能力置于细胞内和细胞间耦合的背景下。我们讨论如何,通过复杂的生物物理机制,轴突扩展的剧目轴突计算,从而,神经计算。
英文摘要:
Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By combining their active and passive biophysical properties, they ensure a plethora of physiological computations. In this review, we revisit the biophysics of generation and propagation of electrical signals in the axon, their complex interplay, and their rich dynamics. We further place the computational abilities of axons in the context of intracellular and intercellular coupling. We discuss how, by means of sophisticated biophysical mechanisms, axons expand the repertoire of axonal computation, and thereby, of neural computation.
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