The development of next generation medicines demand more sensitive and reliable label free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of the main possible technologies to cover the existing gap. The general trend for the sensors has been miniaturisation with the expectation of improving sensitivity and response time, but presenting issues with reproducibility and noise level. Here we propose a Fin-Field Effect Transistor (FinFET) with a high heigth to width aspect ratio for electrochemical biosensing solving the issue of nanosensors in terms of reproducibility and noise, while keeping the fast response time. We fabricated different devices and characterised their performance with their response to the pH changes that fitted to a Nernst-Poisson model. The experimental data were compared with simulations of devices with different aspect ratio, stablishing an advantage in total signal and linearity for the FinFETs with higher aspect ratio. In addition, these FinFETs promise the optimisation of reliability and efficiency in terms of limits of detection, for which the interplay of the size and geometry of the sensor with the diffusion of the analytes plays a pivotal role.
Two-dimensional ZIF-L nanosheets as high performance non-enzymatic glucose sensor
基于二维（2D）Co-ZIF-L纳米片，开发了一种高效的葡萄糖非酶电化学检测生物传感器。制备的Co-ZIF-L纳米片电极表现出优异的性能，具有769.5 × 10 $^{-6}$ A mM $^{-1}$ cm $^{-2}$的较高灵敏度和90.4 nM的较低检测限，而构建的3D ZIF-67纳米颗粒电极显示出较弱的灵敏度，为697.4 × 10 $^{-6}$ A mM $^{-1}$ cm $^{-2}$，并且检测范围有限，为2 × 10 10 15 mM。10 $^{-6}$ M至414 *10 $^{-6}$ M。此外，基于Co-ZIF-L的非酶葡萄糖生物传感器具有可接受的选择性、长期稳定性以及重现性。这项工作可能提供一种新的方法来开发二维ZIF纳米片作为电化学生物传感器的潜在候选者。
Synergistic Effect of Multi-Walled Carbon Nanotubes and Ladder-Type Conjugated Polymers on the Performance of N-Type Organic Electrochemical Transistors
Local Multimodal Dynamics in Mixed Ionic-Electronic Conductors and Their Fingerprints in Organic Electrochemical Transistor Operation
Institut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST)（巴塞罗那生物工程研究所，巴塞罗那科学技术研究院）；Center for Nano Science and Technology, Istituto Italiano di Tecnologia（意大利理工学院纳米科学和技术中心）；Laboratory of Organic Electronics, Department of Science and Technology (ITN), Linköping University（林雪平大学科技学院有机电子实验室）；Department d'Enginyeria Electrònica i Biomèdica, Universitat de Barcelona（巴塞罗那大学生物医学电子工程系）；Center for Nanophase Materials Sciences, Oak Ridge National Laboratory（橡树岭国家实验室纳米相材料科学中心）
