Recently Hui et al. (2018) use F tests for testing a subset of random effect, demonstrating its computational simplicity and exactness when the first two moment of the random effects are specified. We extended the investigation of the F test in the following two aspects: firstly, we examined the power of the F test under non-normality of the errors. Secondly, we consider bootstrap counterparts to the F test, which offer improvement for the cases with small cluster size or for the cases with non-normal errors.
Linear mixed-effects models are commonly used to analyze clustered data structures. There are numerous packages to fit these models in R and conduct likelihood-based inference. The implementation of resampling-based procedures for inference are more limited. In this paper, we introduce the lmeresampler package for bootstrapping nested linear mixed-effects models fit via lme4 or nlme. Bootstrap estimation allows for bias correction, adjusted standard errors and confidence intervals for small samples sizes and when distributional assumptions break down. We will also illustrate how bootstrap resa…
An algorithm is described that enables efficient deterministic approximate computation of the bootstrap distribution for any linear bootstrap method $T_n^*$, alleviating the need for repeated resampling from observations (resp. input-derived data). In essence, the algorithm computes the distribution function from a linear mixture of independent random variables each having a finite discrete distribution. The algorithm is applicable to elementary bootstrap scenarios (targetting the mean as parameter of interest), for block bootstrap, as well as for certain residual bootstrap scenarios. Moreover…
Statistics derived from the eigenvalues of sample covariance matrices are called spectral statistics, and they play a central role in multivariate testing. Although bootstrap methods are an established approach to approximating the laws of spectral statistics in low-dimensional problems, these methods are relatively unexplored in the high-dimensional setting. The aim of this paper is to focus on linear spectral statistics as a class of prototypes for developing a new bootstrap in high-dimensions --- and we refer to this method as the Spectral Bootstrap. In essence, the method originates from t…
We present a brief overview of the methods for making statistical inference (testing statistical hypotheses, construction of confidence and/or prediction intervals and regions) about linear functions of the fixed effects and/or about the fixed and random effects simultaneously, in conventional simple linear mixed model. The presented approach is based on solutions from the Henderson's mixed model equations.
Considerable interest has recently been focused on studying multiple phenotypes simultaneously in both epidemiological and genomic studies, either to capture the multidimensionality of complex disorders or to understand shared etiology of related disorders. We seek to identify {\em multiple regulators} or predictors that are associated with multiple outcomes when these outcomes may be measured on very different scales or composed of a mixture of continuous, binary, and not-fully-observed elements. We first propose an estimation technique to put all effects on similar scales, and we induce spar…
We propose a new omnibus test for vector white noise using the maximum absolute auto-correlations and cross-correlations of the component series. Based on the newly established approximation by the $L_\infty$-norm of a normal random vector, the critical value of the test can be evaluated by bootstrapping from a multivariate normal distribution. In contrast to the conventional white noise test, the new method is proved to be valid for testing the departure from non-IID white noise. We illustrate the accuracy and the power of the proposed test by simulation, which also shows that the new test ou…
Generalized linear mixed models (GLMMs) are used to model responses from exponential families with a combination of fixed and random effects. For variance components in GLMMs, we propose an approximate restricted likelihood ratio test that conducts testing on the working responses used in penalized quasi-likelihood estimation. This presents the hypothesis test in terms of normalized responses, allowing for application of existing testing methods for linear mixed models. Our test is flexible, computationally efficient, and outperforms several competitors. We illustrate the utility of the propos…
Throughout the last decade, random forests have established themselves as among the most accurate and popular supervised learning methods. While their black-box nature has made their mathematical analysis difficult, recent work has established important statistical properties like consistency and asymptotic normality by considering subsampling in lieu of bootstrapping. Though such results open the door to traditional inference procedures, all formal methods suggested thus far place severe restrictions on the testing framework and their computational overhead precludes their practical scientifi…
The issue of variance components testing arises naturally when building mixed-effects models, to decide which effects should be modeled as fixed or random. While tests for fixed effects are available in R for models fitted with lme4, tools are missing when it comes to random effects. The varTestnlme package for R aims at filling this gap. It allows to test whether any subset of the variances and covariances corresponding to any subset of the random effects, are equal to zero using asymptotic property of the likelihood ratio test statistic. It also offers the possibility to test simultaneously …
The parametric Welch $t$-test and the non-parametric Wilcoxon-Mann-Whitney test are the most commonly used two independent sample means tests. More recent testing approaches include the non-parametric, empirical likelihood and exponential empirical likelihood. However, the applicability of these non-parametric likelihood testing procedures is limited partially because of their tendency to inflate the type I error in small sized samples. In order to circumvent the type I error problem, we propose simple calibrations using the $t$ distribution and bootstrapping. The two non-parametric likelihood…
We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for SNP set analysis in genetic association studies. We derive a class of analytic approximate Bayes factors and illustrate their connections with a variety of frequentist test statistics, including the Wald statistic and the variance component score statistic. Taking advantage of Bayesian model averaging and hierarchical modeling, we demonstrate some distinct advantages and flex…
This paper studies the high-dimensional mixed linear regression (MLR) where the output variable comes from one of the two linear regression models with an unknown mixing proportion and an unknown covariance structure of the random covariates. Building upon a high-dimensional EM algorithm, we propose an iterative procedure for estimating the two regression vectors and establish their rates of convergence. Based on the iterative estimators, we further construct debiased estimators and establish their asymptotic normality. For individual coordinates, confidence intervals centered at the debiased …
Mixed Gaussian Projections for Two-Sample Testing of Functional Data
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC (UFABC)（阿贝辛联邦大学数学、计算与认知中心）；Departamento de Matemática, Universidad de San Andrés–CONICET（圣安德烈斯大学数学系-阿根廷国家科学研究委员会）
Mixed linear models are commonly used in repeated measures studies. They account for the dependence amongst observations obtained from the same experimental unit. Oftentimes, the number of observations is small, and it is thus important to use inference strategies that incorporate small sample corrections. In this paper, we develop modified versions of the likelihood ratio test for fixed effects inference in mixed linear models. In particular, we derive a Bartlett correction to such a test and also to a test obtained from a modified profile likelihood function. Our results generalize those in …
University of California San Diego（加州大学圣迭戈分校）；KU Leuven（鲁汶大学）
Many scientific and engineering challenges -- ranging from pharmacokinetic drug dosage allocation and personalized medicine to marketing mix (4Ps) recommendations -- require an understanding of the unobserved heterogeneity in order to develop the best decision making-processes. In this paper, we develop a hypothesis test and the corresponding p-value for testing for the significance of the homogeneous structure in linear mixed models. A robust matching moment construction is used for creating a test that adapts to the size of the model sparsity. When unobserved heterogeneity at a cluster level…
Consider a large social network with possibly severe degree heterogeneity and mixed-memberships. We are interested in testing whether the network has only one community or there are more than one communities. The problem is known to be non-trivial, partially due to the presence of severe degree heterogeneity. We construct a class of test statistics using the numbers of short paths and short cycles, and the key to our approach is a general framework for canceling the effects of degree heterogeneity. The tests compare favorably with existing methods. We support our methods with careful analysis …
As the sequencing costs are decreasing, there is great incentive to perform large scale association studies to increase power of detecting new variants. Federated association testing among different institutions is a viable solution for increasing sample sizes by sharing the intermediate testing statistics that are aggregated by a central server. There are, however, standing challenges to performing federated association testing. Association tests are known to be confounded by numerous factors such as population stratification, which can be especially important in multiancestral studies and in…
Scalar-on-function linear models are commonly used to regress functional predictors on a scalar response. However, functional models are more difficult to estimate and interpret than traditional linear models, and may be unnecessarily complex for a data application. Hypothesis testing can be used to guide model selection by determining if a functional predictor is necessary. Using a mixed effects representation with penalized splines and variance component tests, we propose a framework for testing functional linear models with responses from exponential family distributions. The proposed metho…
In this paper, the problem of error control of stepwise multiple testing procedures is considered. For two-sided hypotheses, control of both type 1 and type 3 (or directional) errors is required, and thus mixed directional familywise error rate control and mixed directional false discovery rate control are each considered by incorporating both types of errors in the error rate. Mixed directional familywise error rate control of stepwise methods in multiple testing has proven to be a challenging problem, as demonstrated in Shaffer (1980). By an appropriate formulation of the problem, some new s…
We consider three problems in high-dimensional Gaussian linear mixed models. Without any assumptions on the design for the fixed effects, we construct an asymptotic $F$-statistic for testing whether a collection of random effects is zero, derive an asymptotic confidence interval for a single random effect at the parametric rate $\sqrt{n}$, and propose an empirical Bayes estimator for a part of the mean vector in ANOVA type models that performs asymptotically as well as the oracle Bayes estimator. We support our results with numerical simulations and provide comparisons with oracle estimators. …
The group testing approach that achieves significant cost reduction over the individual testing approach has received a lot of interest lately for massive testing of COVID-19. Many studies simply assume samples mixed in a group are independent. However, this assumption may not be reasonable for a contagious disease like COVID-19. Specifically, people within a family tend to infect each other and thus are likely to be positively correlated. By exploiting positive correlation, we make the following two main contributions. One is to provide a rigorous proof that further cost reduction can be achi…
Over the past decades, linear mixed models have attracted considerable attention in various fields of applied statistics. They are popular whenever clustered, hierarchical or longitudinal data are investigated. Nonetheless, statistical tools for valid simultaneous inference for mixed parameters are rare. This is surprising because one often faces inferential problems beyond the pointwise examination of fixed or mixed parameters. For example, there is an interest in a comparative analysis of cluster-level parameters or subject-specific estimates in studies with repeated measurements. We discuss…
