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arXiv 1811.02414stat.ME
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基于Copula的稳健最优区组设计

Copula-based robust optimal block designs

W. G. Mueller, A. Rappold, D. C. Woods

摘要:

在设计的实验中,通过将同质的实验单元收集在一起,通常使用分块来减少已知的变异性。这种实验的一个常见的建模假设是,来自块内单元的响应是相关的。当响应不是正态分布时,在实验设计和所得数据的建模中考虑这种依赖性可能具有挑战性,特别是在找到最佳设计所需的计算方面。Copula和边际建模的应用为估计群体平均处理效应提供了一种计算效率高的方法。从材料测试的实验的动机,我们开发和演示设计与块大小为2 copula模型。这样的设计在从微阵列实验到对人类眼睛或四肢的实验的应用中也很重要,这些实验具有天然存在的大小为2的块。我们目前的设计选择方法,在文献中现有的方法进行比较,并评估建模假设的设计的鲁棒性。

英文摘要:

Blocking is often used to reduce known variability in designed experiments by collecting together homogeneous experimental units. A common modelling assumption for such experiments is that responses from units within a block are dependent. Accounting for such dependencies in both the design of the experiment and the modelling of the resulting data when the response is not normally distributed can be challenging, particularly in terms of the computation required to find an optimal design. The application of copulas and marginal modelling provides a computationally efficient approach for estimating population-average treatment effects. Motivated by an experiment from materials testing, we develop and demonstrate designs with blocks of size two using copula models. Such designs are also important in applications ranging from microarray experiments to experiments on human eyes or limbs with naturally occurring blocks of size two. We present methodology for design selection, make comparisons to existing approaches in the literature and assess the robustness of the designs to modelling assumptions.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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