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arXiv 1810.03382cs.LGcs.CVstat.ML
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用于人类生存预测的深度学习心脏运动分析

Deep learning cardiac motion analysis for human survival prediction

National Heart and Lung Institute, Imperial College London, UK(英国帝国理工学院国家心肺研究所);Department of Computing, Imperial College London, UK(英国帝国理工学院计算机系);Imperial College Healthcare NHS Trust, London, UK(英国伦敦帝国理工学院医疗NHS信托基金);Division of Experimental Medicine, Department of Medicine, Imperial College London, UK(英国帝国理工学院医学系实验医学部);National Heart Centre Singapore, Singapore, and Duke-NUS Graduate Medical School, Singapore(新加坡国家心脏中心和新加坡杜克-新加坡国立大学医学院)
Ghalib A. Bello, Timothy J. W. Dawes, Jinming Duan, Carlo Biffi, Antonio de Marvao, Luke S. G. E. Howard, J. Simon R. Gibbs, Martin R. Wilkins, Stuart A. Cook, … 展开作者

Ghalib A. Bello, Timothy J. W. Dawes, Jinming Duan, Carlo Biffi, Antonio de Marvao, Luke S. G. E. Howard, J. Simon R. Gibbs, Martin R. Wilkins, Stuart A. Cook, Daniel Rueckert, Declan P. O'Regan

摘要:

在计算机视觉中,运动分析用于理解图像序列中运动对象的行为。优化动态生物系统的解释需要准确和精确的运动跟踪以及高维运动轨迹的有效表示,以便这些可以用于预测任务。在这里,我们使用心脏磁共振成像获取的心脏图像序列,使用在解剖形状先验上训练的完全卷积网络来创建时间分辨的三维分割。这种密集的运动模型形成了监督去噪自动编码器(4Dsurvival)的输入,这是一个混合网络,由一个自动编码器组成,该自动编码器学习在观察到的结果数据上训练的特定于任务的潜在代码表示,产生针对生存预测优化的潜在表示。为了处理右删失的生存结果,我们的网络使用了Cox偏似然损失函数。在一项302例患者的研究中,我们的模型C=0.73(95 $\%$ CI:0.68 - 0.78)的预测准确性(由Harrell C指数量化)显著高于(p <0.0001)人类基准C=0.59(95 $\%$ CI:0.53 - 0.65)。这项工作演示了如何使用高维医学图像数据的复杂计算机视觉任务可以有效地预测人类的生存。

英文摘要:

Motion analysis is used in computer vision to understand the behaviour of moving objects in sequences of images. Optimising the interpretation of dynamic biological systems requires accurate and precise motion tracking as well as efficient representations of high-dimensional motion trajectories so that these can be used for prediction tasks. Here we use image sequences of the heart, acquired using cardiac magnetic resonance imaging, to create time-resolved three-dimensional segmentations using a fully convolutional network trained on anatomical shape priors. This dense motion model formed the input to a supervised denoising autoencoder (4Dsurvival), which is a hybrid network consisting of an autoencoder that learns a task-specific latent code representation trained on observed outcome data, yielding a latent representation optimised for survival prediction. To handle right-censored survival outcomes, our network used a Cox partial likelihood loss function. In a study of 302 patients the predictive accuracy (quantified by Harrell's C-index) was significantly higher (p < .0001) for our model C=0.73 (95$\%$ CI: 0.68 - 0.78) than the human benchmark of C=0.59 (95$\%$ CI: 0.53 - 0.65). This work demonstrates how a complex computer vision task using high-dimensional medical image data can efficiently predict human survival.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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