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arXiv 1809.03078q-bio.PE
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分子系统发育建模中的系统学和对称性:物理学观点

Systematics and symmetry in molecular phylogenetic modelling: perspectives from physics

Peter D Jarvis, Jeremy G Sumner

摘要:

这篇综述的目的是介绍和分析近年来在生物学中广泛使用的数学遗传学的概率模型,作为推断和重建物种之间祖先关系的基石。我们概述了理论遗传学的发展,从最早的基于形态特征的研究,通过使用各种形式的分子数据。我们把镜头的数学物理承担的理论模型的制定,集中在适用性的许多方法,从工具包的传统-技术组和表示,以指导模型规范,并利用多线性设置的模型中存在的基本对称性;对与模型下的速率矩阵相关联的生成器的共代数性质的扩展,关于形成用于推断进化树的搜索空间的图形结构(树和网络)。所提出的方面,包括相关的模型类相关的矩阵李代数,以及操纵组字符枚举各种自然多项式不变量,用于识别鲁棒的,低参数的数量用于推理。最重要的是,我们希望强调多体纠缠的许多特征,这些特征在物理学方面的量子态描述和遗传学中出现的多路张量概率阵列之间是共享的。在某些情况下,众所周知的对象,如凯莱超行列式(“纠结”)可以直接导入到形式主义-模型与二进制字符特征,和三胞胎的类群。在其他情况下,新的对象出现,如显着的五次'squangle'不变量的四叉树歧视和DNA数据,与自己独特的解释系统发育建模的背景下。

英文摘要:

The aim of this review is to present and analyze the probabilistic models of mathematical phylogenetics which have been intensively used in recent years in biology as the cornerstone of attempts to infer and reconstruct the ancestral relationships between species. We outline the development of theoretical phylogenetics, from the earliest studies based on morphological characters, through to the use of molecular data in a wide variety of forms. We bring the lens of mathematical physics to bear on the formulation of theoretical models, focussing on the applicability of many methods from the toolkit of that tradition -- techniques of groups and representations to guide model specification and to exploit the multilinear setting of the models in the presence of underlying symmetries; extensions to coalgebraic properties of the generators associated to rate matrices underlying the models, in relation to the graphical structures (trees and networks) which form the search space for inferring evolutionary trees. Aspects presented, include relating model classes to relevant matrix Lie algebras, as well as manipulations with group characters to enumerate various natural polynomial invariants, for identifying robust, low-parameter quantities for use in inference. Above all, we wish to emphasize the many features of multipartite entanglement which are shared between descriptions of quantum states on the physics side, and the multi-way tensor probability arrays arising in phylogenetics. In some instances, well-known objects such as the Cayley hyperdeterminant (the `tangle') can be directly imported into the formalism -- for models with binary character traits, and triplets of taxa. In other cases new objects appear, such as the remarkable quintic `squangle' invariants for quartet tree discrimination and DNA data, with their own unique interpretation in the phylogenetic modeling context.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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