High fidelity fibre-based physiological sensing deep in tissue

模拟难治性心脏组织的生理准确性：体积平均双域模型与基于细胞的EMI模型对比

Physiological accuracy in simulating refractory cardiac tissue: the volume-averaged bidomain model vs. the cell-based EMI model

本研究比较了双域模型和EMI模型生成的单极SI曲线，发现EMI模型因解析细胞结构而更准确地反映心脏组织的难治期行为，为未来计算起搏器模拟提供了重要参考。

Acousto-elasticity of Transversely Isotropic Incompressible Soft Tissues: Characterization of Skeletal Striated Muscle

Using shear wave elastography, we measure the changes in the wave speed with the stress produced by a striated muscle during isometric voluntary contraction. To isolate the behaviour of an individual muscle from complementary or antagonistic actions of adjacent muscles, we select the flexor digiti minimi muscle, whose sole function is to extend the little finger. To link the wave speed to the stiffness, we develop an acousto-elastic theory for shear waves in homogeneous, transversely isotropic, incompressible solids subject to uniaxial stress. We then provide measurements of the apparent shear…

丝绸模板纳米带作为超质子纤维传感器

Silk-templated Nanostrips as Superprotonic Fibre Sensors

本研究利用丝绸纤维模板生长MOF纳米带，构建超质子界面，实现高电导率柔性纤维传感器，用于高精度呼吸监测和动态湿度映射。

利用生成式深度学习增强定量光声断层成像的合成训练数据

Enhancing synthetic training data for quantitative photoacoustic tomography with generative deep learning

针对定量光声断层成像中合成训练数据泛化性差的问题，提出利用CycleGAN域自适应和AmbientGAN生成配对数据两种生成对抗网络策略，以提升sO2估计网络在真实组织上的性能。

Quantitative phase and polarisation endoscopy applied to detection of early oesophageal tumourigenesis

Phase and polarisation of coherent light are highly perturbed by interaction with microstructural changes in pre-malignant tissue, holding promise for label-free early cancer detection in endoscopically accessible tissues such as the gastrointestinal tract. Flexible optical fibres used in conventional diagnostic endoscopy scramble phase and polarisation, restricting clinicians instead to low-contrast amplitude-only imaging. Here, we unscramble phase and polarisation images by exploiting the near-diagonal multi-core fibre (MCF) transmission matrix to create a novel parallelised fibre characteri…

High-fidelity multimode fibre-based endoscopy for deep-brain in vivo imaging

Progress in neuroscience constantly relies on the development of new techniques to investigate the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally-invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas. A perspective strategy is to utilise holographic control of light propagation in complex media, which allows converting a hair-thin multimode optical fibre into an ultra-narrow imaging tool. Compared to current endoscopes based on GRIN lenses or fibre bundles, this concept offers a footprint reduction exceeding an order…

Ultrathin, high-speed, all-optical photoacoustic endomicroscopy probe for guiding minimally invasive surgery

Photoacoustic (PA) endoscopy has shown significant potential for clinical diagnosis and surgical guidance. Multimode fibres (MMFs) are becoming increasing attractive for the development of miniature endoscopy probes owing to ultrathin size, low cost and diffraction-limited spatial resolution enabled by wavefront shaping. However, current MMF-based PA endomicroscopy probes are either limited by a bulky ultrasound detector or a low imaging speed which hindered their usability. In this work, we report the development of a highly miniaturised and high-speed PA endomicroscopy probe that is integrat…

生理氧和盐条件下超高剂量率照射DNA的 sparing 效应

Sparing of DNA irradiated with Ultra-High Dose-Rates under Physiological Oxygen and Salt conditions

本研究首次在生理氧和盐条件下观察到超高剂量率照射对质粒DNA的sparing效应，并提出了基于氧与羟基自由基相互作用的模型来解释该现象。

Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues

Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation by tissue optical properties, an effect that causes spectral corruption. Predictions of the spectral variations of light fluence in tissue are challenging since the spatial distribution of optical properties in tissue cannot be resolved in high resolution or with high accuracy by current methods. Spectral corruption has fundamentally limited the quantification accuracy of optical and optoacoustic methods and impeded the long sought-after goal of imaging blood oxygen saturati…

用于深层组织生物电记录的电学功能化体表

Electrically functionalized body surface for deep-tissue bioelectrical recording

本文提出在体表直接喷涂二维纳米片墨水形成共形 VDWTF-EFBS，以低阻抗和抗运动伪影实现深层组织生物电信号的连续无创监测。

多模态成像系统：结合超光谱成像与激光散斑成像用于活体血流和代谢监测

Multimodal Imaging System Combining Hyperspectral and Laser Speckle Imaging for In Vivo Hemodynamic and Metabolic Monitoring

本研究提出了一种结合超光谱和激光散斑成像的多模态成像系统，用于实时监测活体组织的血流和代谢状态。