微流控环境中基于磁性纳米粒子的分子通讯
Magnetic Nanoparticle Based Molecular Communication in Microfluidic Environments
摘要：
以非侵入性方式引导和控制磁性纳米颗粒的可能性已经在生物技术中产生了各种应用，例如靶向药物递送和生物物质的感测。这些应用通过所用颗粒的尺寸、选择性化学反应性和一般化学组成的工程化来促进。由于磁性纳米粒子具有广泛的用途和良好的性质，在本文中，我们对磁性纳米粒子在分子通信系统设计中的潜在益处进行了理论研究。特别是，我们认为磁性纳米粒子为基础的通信在微流体通道中的外部磁场被用来吸引携带信息的颗粒的接收器。我们表明，布朗运动，流体流动，和外部磁场的影响下的粒子输运可以在数学上模拟为漂移扩散。因此，我们揭示了决定磁力的关键参数是颗粒尺寸和磁场梯度。此外，我们推导出的通道脉冲响应，这是用来评估由于磁场的预期数量的观察到的纳米粒子的潜在增益的解析表达式。此外，采用符号出错率作为性能指标，我们表明，使用磁性纳米粒子可以实现可靠的通信中存在的破坏性流体流。基于粒子模拟的数值结果验证了解析表达式的准确性。
英文摘要：
The possibility to guide and control magnetic nanoparticles in a non-invasive manner has spawned various applications in biotechnology such as targeted drug delivery and sensing of biological substances. These applications are facilitated by the engineering of the size, selective chemical reactivity, and general chemical composition of the employed particles. Motivated by their widespread use and favorable properties, in this paper, we provide a theoretical study of the potential benefits of magnetic nanoparticles for the design of molecular communication systems. In particular, we consider magnetic nanoparticle based communication in a microfluidic channel where an external magnetic field is employed to attract the information-carrying particles to the receiver. We show that the particle transport affected by Brownian motion, fluid flow, and an external magnetic field can be mathematically modeled as diffusion with drift. Thereby, we reveal that the key parameters determining the magnetic force are the particle size and the magnetic field gradient. Moreover, we derive an analytical expression for the channel impulse response, which is used to evaluate the potential gain in the expected number of observed nanoparticles due to the magnetic field. Furthermore, adopting the symbol error rate as performance metric, we show that using magnetic nanoparticles can enable reliable communication in the presence of disruptive fluid flow. Numerical results obtained by particle-based simulation validate the accuracy of the derived analytical expressions.
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