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arXiv 1807.03043cs.CV
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基于卷积循环神经网络的血糖预测

Convolutional Recurrent Neural Networks for Glucose Prediction

Imperial College London(帝国理工学院)

Kezhi Li, John Daniels, Chengyuan Liu, Pau Herrero, Pantelis Georgiou

摘要:

控制血糖对于糖尿病管理至关重要。目前用于1型糖尿病(T1 DM)受试者的数字治疗方法(如人工胰腺和胰岛素推注计算器)利用机器学习技术预测皮下葡萄糖,以改善控制。深度学习最近已被应用于医疗保健和医学研究,以在一系列任务中实现最先进的结果,包括疾病诊断和患者状态预测等。在这项工作中,我们提出了一个深度学习模型,该模型能够预测模拟患者病例的血糖水平,具有领先的准确性(30分钟范围内RMSE = 9.38 $\pm$ 0.71 [mg/dL],RMSE = 18.87 $\pm$ 2.25 [mg/dL](60分钟范围内)和真实患者病例(30分钟RMSE = 21.07 $\pm$ 2.35 [mg/dL],60分钟RMSE = 33.27 $\pm$ 4.79\%)。此外,本发明还提供了一种方法,该模型在提供有效的预测范围方面具有竞争力($PH_{eff}$),在模拟患者数据集中具有最小时滞(30分钟时$PH_{eff}$ = 29.0 $\pm$ 0.7,60分钟时$PH_{eff}$ = 49.8 $\pm$ 2.9)和真实患者数据集中($PH_{eff}$ = 19.3 $\pm$ 3.1,持续30分钟; $PH_{eff}$ = 29.3 $\pm$ 9.4,持续60分钟)。该方法在UVa/Padova模拟器生成的10个模拟病例的数据集和10个真实病例的临床数据集上进行评价,每个真实病例均包含葡萄糖读数、胰岛素推注和膳食(碳水化合物)数据。循环卷积神经网络的性能是基准对四种算法。所提出的算法是在Android手机上实现的,与在手机上的执行时间相比,$780$ ms在笔记本电脑上的执行时间的$6$毫秒。

英文摘要:

Control of blood glucose is essential for diabetes management. Current digital therapeutic approaches for subjects with Type 1 diabetes mellitus (T1DM) such as the artificial pancreas and insulin bolus calculators leverage machine learning techniques for predicting subcutaneous glucose for improved control. Deep learning has recently been applied in healthcare and medical research to achieve state-of-the-art results in a range of tasks including disease diagnosis, and patient state prediction among others. In this work, we present a deep learning model that is capable of forecasting glucose levels with leading accuracy for simulated patient cases (RMSE = 9.38$\pm$0.71 [mg/dL] over a 30-minute horizon, RMSE = 18.87$\pm$2.25 [mg/dL] over a 60-minute horizon) and real patient cases (RMSE = 21.07$\pm$2.35 [mg/dL] for 30-minute, RMSE = 33.27$\pm$4.79\% for 60-minute). In addition, the model provides competitive performance in providing effective prediction horizon ($PH_{eff}$) with minimal time lag both in a simulated patient dataset ($PH_{eff}$ = 29.0$\pm$0.7 for 30-min and $PH_{eff}$ = 49.8$\pm$2.9 for 60-min) and in a real patient dataset ($PH_{eff}$ = 19.3$\pm$3.1 for 30-min and $PH_{eff}$ = 29.3$\pm$9.4 for 60-min). This approach is evaluated on a dataset of 10 simulated cases generated from the UVa/Padova simulator and a clinical dataset of 10 real cases each containing glucose readings, insulin bolus, and meal (carbohydrate) data. Performance of the recurrent convolutional neural network is benchmarked against four algorithms. The proposed algorithm is implemented on an Android mobile phone, with an execution time of $6$ms on a phone compared to an execution time of $780$ms on a laptop.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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