Magnetic Resonance Angiography (MRA) has become an essential MR contrast for imaging and evaluation of vascular anatomy and related diseases. MRA acquisitions are typically ordered for vascular interventions, whereas in typical scenarios, MRA sequences can be absent in the patient scans. This motivates the need for a technique that generates inexistent MRA from existing MR multi-contrast, which could be a valuable tool in retrospective subject evaluations and imaging studies. In this paper, we present a generative adversarial network (GAN) based technique to generate MRA from T1-weighted and T2-weighted MRI images, for the first time to our knowledge. To better model the representation of vessels which the MRA inherently highlights, we design a loss term dedicated to a faithful reproduction of vascularities. To that end, we incorporate steerable filter responses of the generated and reference images inside a Huber function loss term. Extending the well- established generator-discriminator architecture based on the recent PatchGAN model with the addition of steerable filter loss, the proposed steerable GAN (sGAN) method is evaluated on the large public database IXI. Experimental results show that the sGAN outperforms the baseline GAN method in terms of an overlap score with similar PSNR values, while it leads to improved visual perceptual quality.
Cross-modality image synthesis from TOF-MRA to CTA using diffusion-based models
Charité – Universitätsmedizin Berlin（柏林夏里特医学院）；Freie Universität Berlin（柏林自由大学）；Humboldt-Universität zu Berlin（柏林洪堡大学）；Mie University Graduate School of Medicine（三重大学医学院）；Mie Chuo Medical Center（三重中央医疗中心）
Multi-contrast MRI acquisitions of an anatomy enrich the magnitude of information available for diagnosis. Yet, excessive scan times associated with additional contrasts may be a limiting factor. Two mainstream approaches for enhanced scan efficiency are reconstruction of undersampled acquisitions and synthesis of missing acquisitions. In reconstruction, performance decreases towards higher acceleration factors with diminished sampling density particularly at high-spatial-frequencies. In synthesis, the absence of data samples from the target contrast can lead to artefactual sensitivity or inse…
Generative Adversarial Neural Networks (GANs) are applied to the synthetic generation of prostate lesion MRI images. GANs have been applied to a variety of natural images, is shown show that the same techniques can be used in the medical domain to create realistic looking synthetic lesion images. 16mm x 16mm patches are extracted from 330 MRI scans from the SPIE ProstateX Challenge 2016 and used to train a Deep Convolutional Generative Adversarial Neural Network (DCGAN) utilizing cutting edge techniques. Synthetic outputs are compared to real images and the implicit latent representations indu…
Bilkent University（比尔肯大学）；National Magnetic Resonance Research Center (UMRAM), Bilkent University（比尔肯大学国家磁共振研究中心（UMRAM））；Sabuncu Brain Research Center, Bilkent University（比尔肯大学Sabuncu脑研究中心）；Hacettepe University（哈塞特佩大学）
Acquiring images of the same anatomy with multiple different contrasts increases the diversity of diagnostic information available in an MR exam. Yet, scan time limitations may prohibit acquisition of certain contrasts, and images for some contrast may be corrupted by noise and artifacts. In such cases, the ability to synthesize unacquired or corrupted contrasts from remaining contrasts can improve diagnostic utility. For multi-contrast synthesis, current methods learn a nonlinear intensity transformation between the source and target images, either via nonlinear regression or deterministic ne…
Wavelet-Fusion Diffusion Model for Multimodal Brain MRI Synthesis with Modality and Metadata Conditioning
Department of Psychology & Neuroscience, Auckland University of Technology（心理学与神经科学系，奥克兰技术大学）；Department of Psychiatry, University of Melbourne（精神病学系，墨尔本大学）
University of Dundee（邓迪大学）；University of Cambridge（剑桥大学）；University of Bath（巴斯大学）；East China Normal University（华东师范大学）
MRI synthesis promises to mitigate the challenge of missing MRI modality in clinical practice. Diffusion model has emerged as an effective technique for image synthesis by modelling complex and variable data distributions. However, most diffusion-based MRI synthesis models are using a single modality. As they operate in the original image domain, they are memory-intensive and less feasible for multi-modal synthesis. Moreover, they often fail to preserve the anatomical structure in MRI. Further, balancing the multiple conditions from multi-modal MRI inputs is crucial for multi-modal synthesis. …
WFM: 3D Wavelet Flow Matching for Ultrafast Multi-Modal MRI Synthesis
Department of Computer Science, Stanford University（斯坦福大学计算机科学系）；Machine and Hybrid Intelligence Lab, Feinberg School of Medicine, Northwestern University（北western大学费因伯格医学院机器与混合智能实验室）
本文提出WFM方法，通过学习基于小波空间条件均值的直接流，实现高效多模态MRI合成，单模型在BraTS 2024上达到26.8 dB PSNR和0.94 SSIM，速度比扩散模型快250-1000倍。
Technical University of Munich（慕尼黑工业大学）；Klinikum rechts der Isar（伊萨尔河右岸医院）；Southern University of Science and Technology（南方科技大学）
Synthesizing MR imaging sequences is highly relevant in clinical practice, as single sequences are often missing or are of poor quality (e.g. due to motion). Naturally, the idea arises that a target modality would benefit from multi-modal input, as proprietary information of individual modalities can be synergistic. However, existing methods fail to scale up to multiple non-aligned imaging modalities, facing common drawbacks of complex imaging sequences. We propose a novel, scalable and multi-modal approach called DiamondGAN. Our model is capable of performing exible non-aligned cross-modality…
Cycle-guided Denoising Diffusion Probability Model for 3D Cross-modality MRI Synthesis
Emory University（埃默里大学）；Winship Cancer Institute（温希普癌症研究所）；Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）
A Speech-to-Video Synthesis Approach Using Spatio-Temporal Diffusion for Vocal Tract MRI
Harvard Medical School/Massachusetts General Hospital（哈佛医学院/麻省总医院）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Universidad de Antioquia（安蒂奥基亚大学）；Yale University（耶鲁大学）；University of Maryland School of Dentistry（马里兰大学牙科学院）；University Hospital Erlangen（埃尔朗根大学医院）；Johns Hopkins University（约翰斯·霍普金斯大学）
Anguinus Sculpturae: Compositional Synthesis of Peak-Enhancement Breast DCE-MRI Scans
German Cancer Research Center (DKFZ)（德国癌症研究中心）；Heidelberg University（海德堡大学）；HIDSS4Health – Helmholtz Information and Data Science School for Health（HIDSS4Health – 亥姆霍兹健康信息与数据科学学校）；Helmholtz Imaging（亥姆霍兹成像中心）
Towards General Text-guided Image Synthesis for Customized Multimodal Brain MRI Generation
ShanghaiTech University（上海科技大学）；Shanghai Clinical Research and Trial Center（上海临床研究与试验中心）；Affiliated Hangzhou First People’s Hospital, Xihu University School of Medicine（西湖大学医学院附属杭州市第一人民医院）
Sichuan University（四川大学）；Chengdu University of Information Technology（成都信息工程大学）
Purpose: Different Magnetic resonance imaging (MRI) modalities of the same anatomical structure are required to present different pathological information from the physical level for diagnostic needs. However, it is often difficult to obtain full-sequence MRI images of patients owing to limitations such as time consumption and high cost. The purpose of this work is to develop an algorithm for target MRI sequences prediction with high accuracy, and provide more information for clinical diagnosis. Methods: We propose a deep learning based multi-modal computing model for MRI synthesis with featur…
Phase-map synthesis from magnitude-only MR images using conditional score-based diffusion models with application in training of accelerated MRI reconstruction models
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）；National Institute on Aging（美国国家老龄化研究所）
An important task in image processing and neuroimaging is to extract quantitative information from the acquired images in order to make observations about the presence of disease or markers of development in populations. Having a lowdimensional manifold of an image allows for easier statistical comparisons between groups and the synthesis of group representatives. Previous studies have sought to identify the best mapping of brain MRI to a low-dimensional manifold, but have been limited by assumptions of explicit similarity measures. In this work, we use deep learning techniques to investigate …
Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for second-trimester anomaly screening, for which ultrasound (US) is employed. Although expert sonographers are adept at reading US images, MR images which closely resemble anatomical images are much easier for non-experts to interpret. Thus in this paper we propose to generate MR-like images directly from clinical US images. In medical image analysis such a capability is potentially useful as well, for instance for automatic US-MRI registration and fusion. The proposed model is end…
CardioDiT: Latent Diffusion Transformers for 4D Cardiac MRI Synthesis
Institute for Artificial Intelligence in Cardiovascular Medicine, Medical Faculty of Heidelberg University, Heidelberg University（海德堡大学医学院心血管医学人工智能研究所，海德堡大学）；Department of Cardiology, Angiology, Pneumology, Heidelberg University Hospital（海德堡大学医院心脏病学、血管学、肺病学系）；DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim（德国心血管研究中心（DZHK），海德堡/曼海姆合作站点）；Department of Radiology and Nuclear Medicine, University Medical Center Mannheim（曼海姆大学医学中心放射学与核医学系）；Section for Invasive Cardiology and Electrophysiology, I. Medical Department, Cardiology, Hemostasiology and Intensive Care, University Medical Centre Mannheim（曼海姆大学医学中心第一内科（心脏病学、止血学与重症监护）介入心脏病学与电生理学科）；University Medical Center of the Johannes Gutenberg-University Mainz（美因茨约翰内斯·古腾堡大学医学中心）；Department of Cardiology, Angiology, Hemostasis, and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg（海德堡大学曼海姆医学院曼海姆大学医学中心心脏病学、血管学、止血学与内科重症监护系）
本文提出CardioDiT，一种基于扩散变换器的4D潜在扩散模型，用于合成短轴 cine CMR，通过联合建模空间和时间实现连续心脏动态生成。
University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Normandie Univ（诺曼底大学）；UNIROUEN（鲁昂大学）；UNIHAVRE（勒阿弗尔大学）；INSA Rouen（鲁昂应用科学学院）
Computed tomography (CT) is critical for various clinical applications, e.g., radiotherapy treatment planning and also PET attenuation correction. However, CT exposes radiation during acquisition, which may cause side effects to patients. Compared to CT, magnetic resonance imaging (MRI) is much safer and does not involve any radiations. Therefore, recently, researchers are greatly motivated to estimate CT image from its corresponding MR image of the same subject for the case of radiotherapy planning. In this paper, we propose a data-driven approach to address this challenging problem. Specific…
As a powerful technique in medical imaging, image synthesis is widely used in applications such as denoising, super resolution and modality transformation etc. Recently, the revival of deep neural networks made immense progress in the field of medical imaging. Although many deep leaning based models have been proposed to improve the image synthesis accuracy, the evaluation of the model uncertainty, which is highly important for medical applications, has been a missing part. In this work, we propose to use Bayesian conditional generative adversarial network (GAN) with concrete dropout to improv…
Functional Imaging Constrained Diffusion for Brain PET Synthesis from Structural MRI
University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University（北卡罗来纳大学教堂山分校与北卡罗来纳州立大学生物医学工程联合系）；Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属精神卫生中心）
Make-A-Volume: Leveraging Latent Diffusion Models for Cross-Modality 3D Brain MRI Synthesis
The University of Hong Kong（香港大学）；The Chinese University of Hong Kong（香港中文大学）；Qilu Hospital of Shandong University（山东大学齐鲁医院）；Nanyang Technological University（南洋理工大学）
Segmenting the fine structure of the mouse brain on magnetic resonance (MR) images is critical for delineating morphological regions, analyzing brain function, and understanding their relationships. Compared to a single MRI modality, multimodal MRI data provide complementary tissue features that can be exploited by deep learning models, resulting in better segmentation results. However, multimodal mouse brain MRI data is often lacking, making automatic segmentation of mouse brain fine structure a very challenging task. To address this issue, it is necessary to fuse multimodal MRI data to produ…
University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）
Multiple imaging modalities are often used for disease diagnosis, prediction, or population-based analyses. However, not all modalities might be available due to cost, different study designs, or changes in imaging technology. If the differences between the types of imaging are small, data harmonization approaches can be used; for larger changes, direct image synthesis approaches have been explored. In this paper, we develop an approach based on multi-modal metric learning to synthesize images of diverse modalities. We use metric learning via multi-modal image retrieval, resulting in embedding…
RelA-Diffusion: Relativistic Adversarial Diffusion for Multi-Tracer PET Synthesis from Multi-Sequence MRI
Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill（放射科与生物医学研究成像中心（BRIC）、北卡罗来纳大学教堂山分校）；Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University（生物医学工程联合部门、北卡罗来纳大学教堂山分校和北卡罗来纳州立大学）；Department of Exercise and Sport Science, UNC-CH（运动与体育科学系、UNC-CH）
Lesion-DDPM: Lesion-Enhanced 3D Diffusion for MS MRI Synthesis
University of Texas at Arlington（德克萨斯大学阿灵顿分校）；University of Texas at San Antonio（德克萨斯大学圣安东尼奥分校）；University of Texas at Dallas（德克萨斯大学达拉斯分校）；National Taiwan University Hospital（国立台湾大学医院）；National University of Mongolia（蒙古国立大学）；University of Texas at Austin（德克萨斯大学奥斯汀分校）
MRAnnotator: multi-Anatomy and many-Sequence MRI segmentation of 44 structures
BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院生物医学工程与影像研究所）；Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院诊断、分子与介入放射学系）；Rotterdam School of Management, Erasmus University Rotterdam（伊拉斯姆斯大学鹿特丹管理学院）；East River Medical Imaging（东河医学影像中心）；Department of Radiology, Cornell Medicine（康奈尔医学院放射学系）；Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院温赖克人工智能与人类健康系）
Multiple Sclerosis (MS) is a chronic progressive neurological disease characterized by the development of lesions in the white matter of the brain. T2-fluid-attenuated inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) provides superior visualization and characterization of MS lesions, relative to other MRI modalities. Longitudinal brain FLAIR MRI in MS, involving repetitively imaging a patient over time, provides helpful information for clinicians towards monitoring disease progression. Predicting future whole brain MRI examinations with variable time lag has only been attempte…
Brain age estimation based on magnetic resonance imaging (MRI) is an active research area in early diagnosis of some neurodegenerative diseases (e.g. Alzheimer, Parkinson, Huntington, etc.) for elderly people or brain underdevelopment for the young group. Deep learning methods have achieved the state-of-the-art performance in many medical image analysis tasks, including brain age estimation. However, the performance and generalisability of the deep learning model are highly dependent on the quantity and quality of the training data set. Both collecting and annotating brain MRI data are extreme…
T-CACE: A Time-Conditioned Autoregressive Contrast Enhancement Multi-Task Framework for Contrast-Free Liver MRI Synthesis, Segmentation, and Diagnosis
Department of Computer Science, Toronto Metropolitan University（计算机科学系，多伦多 Metropolitan 大学）；School of Biomedical Engineering, Western University（生物医学工程学院，西部大学）
