多尺度方法描述细胞内和离体条件下沿肌动蛋白丝传播的电脉冲
A Multi-Scale Approach to Describe Electrical Impulses Propagating along Actin Filaments in both Intracellular and In-vitro Conditions
摘要：
准确和有效的表征细胞骨架丝的电特性是关键的电信号传播，束和网络的形成，以及其他相关的物理化学过程与真核细胞的生物功能和潜在的纳米技术应用的分子理解。在这篇文章中，我们介绍了一种创新的多尺度方法，能够解释蛋白质分子结构的原子细节，其生物环境，以及它们对沿野生型肌动蛋白丝传播的电脉冲的影响。该方法提供了一种新颖的，简单的，准确的，近似的解析表达式的特征的电脉冲的形状的孤子波形。它已被成功地用于确定电解质条件和电压刺激的电脉冲的形状，衰减和核传播速度在这些系统中的影响。我们的研究结果预测的传播电信号脉冲的形式孤子的电压刺激和电解质溶液的范围内通常存在于细胞内和体外条件。这种多尺度理论也适用于其他高电荷棒状聚电解质与相关的生物医学和生物物理学。它还能够解释病理条件下经常出现的分子结构构象（突变）和生物环境（质子化/去质子化）变化。
英文摘要：
An accurate and efficient characterization of the polyelectrolyte properties for cytoskeleton filaments are key to the molecular understanding of electrical signal propagation, bundle and network formation, as well as other relevant physicochemical processes associated with biological functions in eukaryotic cells and their potential nanotechnological applications. In this article, we introduce an innovative multi-scale approach able to account for the atomistic details of a proteins molecular structure, its biological environment, and their impact on electrical impulses propagating along wild type Actin filaments. The approach provides a novel, simple, accurate, approximate analytic expression for the characterization of electrical impulses in the shape of soliton waveforms. It has been successfully used to determine the effects of electrolyte conditions and voltage stimulus on the electrical impulse shape, attenuation and kern propagation velocity in these systems. Our results predict the propagation of electrical signal impulses in the form of solitons for the range of voltage stimulus and electrolyte solutions typically present in intracellular and in-vitro conditions. This multi-scale theory may also be applicable to other highly charged rod-like polyelectrolytes with relevance in biomedicine and biophysics. It is also able to account for molecular structure conformation (mutation) and biological environment (protonations/deprotonations) changes often present in pathological conditions.
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