空间作图揭示多头绒泡菌伤口愈合的多步骤模式
Spatial mapping reveals multi-step pattern of wound healing in Physarum polycephalum
摘要：
创伤是一种严重的功能损害，特别是对于暴露的有机体，如形成网络的真正的黏菌多头绒泡菌。构成生物体平面的管状网络是完全相互连接的，并且共享一个共同的细胞质。封闭的管壁的振荡收缩驱动细胞质的穿梭流动。细胞质流动是网络重组的基础，例如通过朝向吸引刺激物或远离排斥物的运动。在这里，我们跟踪了严重受伤后多头绒泡菌网络的重组。空间映射的收缩变化，在响应创伤揭示了一个多步骤的模式。活动增加的阶段与收缩的停止和流动的停滞交替出现，从而在切断部位引起协调的运输和生长。总的来说，切断令人惊讶地像一个有吸引力的刺激，使切断管愈合。在这种伤口愈合反应过程中产生的可重复的收缩停止可能会开辟新的途径来研究多头绒泡菌复杂行为背后的生化布线。
英文摘要：
Wounding is a severe impairment of function, especially for an exposed organism like the network-forming true slime mould Physarum polycephalum. The tubular network making up the organism's body plan is entirely interconnected and shares a common cytoplasm. Oscillatory contractions of the enclosing tube walls drive the shuttle streaming of the cytoplasm. Cytoplasmic flows underlie the reorganization of the network for example by movement toward attractive stimuli or away from repellants. Here, we follow the reorganization of Physarum polycephalum networks after severe wounding. Spatial mapping of the contraction changes in response to wounding reveal a multi-step pattern. Phases of increased activity alternate with cessation of contractions and stalling of flows, giving rise to coordinated transport and growth at the severing site. Overall, severing surprisingly acts like an attractive stimulus enabling healing of severed tubes. The reproducible cessation of contractions arising during this wound-healing response may open up new venues to investigate the biochemical wiring underlying Physarum polycephalum's complex behaviours.
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