生物细胞共振器
Biological Cell Resonators
摘要：
本论文发展回音壁模式的理论，探索在什么条件下，微或纳米器件可以维持这些谐振，以及哪些物理标准的谐振条件恶化。然后，研究扩展到考虑生物细胞中的模式是明确持续没有人工援助。谐振器的特性及其发射的能量谱在时域有限差分法的一般框架内进行研究，需要超级计算资源来探测电磁场之间的瞬态行为和相互作用。Mie散射的正式理论也扩展到开发一个尖端的，计算效率高的模型，一般，多层微球，这代表了一个有价值的成就，为科学界本身的权利。该模型将数学建模领域的方法统一起来，以一个单一的包含方程来表达能谱，然后将其应用于一系列环境中。建模和生物谐振器之间的鸿沟是通过深入研究一系列生物细胞的物理特性来弥合的，可行的谐振器候选人的选择标准是通过一些详细的可行性研究来制定的。因此，牛胚胎被选为本研究的最佳选择。证据是建立的牛胚胎的能力，以维持回音壁模式。细胞自身维持模式的能力代表了涉及现场细胞询问和报告未来生物细胞状态和健康的新技术的概念上的优雅范例。因此，本文所包含的方法和技术发展成为未来实现自主生物细胞传感器的重要资产。
英文摘要：
This thesis develops the theory of whispering gallery modes, exploring under what conditions a micro or nanoscale device can sustain these resonances, and for which physical criteria the resonance conditions deteriorate. The study is then extended to consider the biological cell in which modes are definitively sustained without artificial assistance. The properties of resonators and their emitted energy spectra are studied within the general framework of the Finite Difference Time Domain method, requiring supercomputing resources to probe the transient behaviour and interactions among the electromagnetic fields. The formal theory of Mie scattering is also extended to develop a cutting-edge, computationally efficient model for general, multilayer microspheres, which represents a valuable achievement for the scientific community in its own right. The model unifies the approaches in the field of mathematical modelling to express the energy spectrum in a single encompassing equation, which is then applied in a range of contexts. The gulf between modelling and biological resonators is bridged by an in-depth study of the physical characteristics of a range of biological cells, and the selection criteria for viable resonator candidates are developed through a number of detailed feasibility studies. The bovine embryo is consequently selected as the optimal choice for this investigation. Evidence is established for the ability of a bovine embryo to sustain whispering gallery modes. The ability of a cell to sustain modes on its own represents a conceptually elegant paradigm for new technologies involving on-site cell interrogation and reporting of the status and health of a biological cell in the future. The methodological and technological developments contained herein thus become a vital asset for the future realisation of autonomous biological cell sensors.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
