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arXiv 1709.01469math.AP
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具有奇异位势的多种群Cahn-Hilliard-Darcy肿瘤生长模型

On a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials

Sergio Frigeri, Kei Fong Lam, Elisabetta Rocca, Giulio Schimperna

摘要:

我们考虑一个模型,该模型描述了宿主组织内肿瘤的演变,参数分别为$φ_p$、$φ_d$(增殖细胞和死亡细胞)、$u$(细胞速度)和$n$(营养浓度)。变量$φ_p$、$φ_d$满足具有非零强迫项的Cahn-Hilliard型系统(意味着它们的空间平均值在时间上不守恒),而$u$服从达西定律的形式,$n$满足准静态扩散方程。本工作的主要新颖之处在于,我们能够考虑奇异型的配置潜力,这意味着浓度矢量$(φ_p,φ_d)$被限制在物理允许的值的范围内。另一方面,鉴于非零强迫项的存在,这种选择引起了一些数学困难,特别是涉及到控制$φ_p$和$φ_d$的平均值。对于所得到的数学问题,通过施加适当的初边值条件,我们的主要结果是在适当的正则类中存在弱解。

英文摘要:

We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $φ_p$, $φ_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The variables $φ_p$, $φ_d$ satisfy a Cahn-Hilliard type system with nonzero forcing term (implying that their spatial means are not conserved in time), whereas $u$ obeys a form of the Darcy law and $n$ satisfies a quasistatic diffusion equation. The main novelty of the present work stands in the fact that we are able to consider a configuration potential of singular type implying that the concentration vector $(φ_p,φ_d)$ is constrained to remain in the range of physically admissible values. On the other hand, in view of the presence of nonzero forcing terms, this choice gives rise to a number of mathematical difficulties, especially related to the control of the mean values of $φ_p$ and $φ_d$. For the resulting mathematical problem, by imposing suitable initial-boundary conditions, our main result concerns the existence of weak solutions in a proper regularity class.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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