发育变异性对细胞群体动态和自组织的影响
Effects of developmental variability on the dynamics and self-organization of cell populations
摘要：
我们报告了细胞群体时空斑图形成的实验和理论结果，其中参数在空间和时间上因系统固有的机制而变化，即Dictyosteelium discoideum（D. d.）在饥饿阶段。我们发现，当种群在不同的发育阶段被初始化时，或者，当种群在不同的初始发育阶段被混合时，会形成不同的模式。实验观察到的模式可以用修改的Kessler-Levine模型来理解，该模型考虑了细胞群体的初始空间异质性和我们引入的发育路径，即，各种生化参数的时间依赖性。该参数的动力学与已知的生物化学研究一致。最重要的是，修改后的模型不仅再现了我们的结果，而且还再现了先前发表的独立实验的观察结果。这表明，斑图形成可以用来理解和量化的系统参数的时间演变。
英文摘要：
We report experimental and theoretical results on spatiotemporal pattern formation in cell populations, where the parameters vary in space and time due to mechanisms intrinsic to the system, namely Dictyostelium discoideum (D.d.) in the starvation phase. We find that different patterns are formed when the populations are initialized at different developmental stages, or, when populations at different initial developmental stages are mixed. The experimentally observed patterns can be understood with a modified Kessler-Levine model that takes into account the initial spatial heterogeneity of the cell populations and a developmental path introduced by us, i.e., the time dependence of the various biochemical parameters. The dynamics of the parameter agree with known biochemical studies. Most importantly the modified model reproduces not only our results, but also the observations of an independent experiment published earlier. This shows that pattern formation can be used to understand and quantify the temporal evolution of the system parameters.
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