受信号梯度控制的顺序斑图形成
Sequential pattern formation governed by signaling gradients
摘要：
在所有脊椎动物物种中，胚胎体平面的有节奏和顺序的分割是一个重要的发育模式化过程。然而，从细胞振荡与组织伸长和缩短以及与信号梯度的相互作用中捕获基因表达动态模式的出现的理论框架仍然缺失。在这里，我们表明，一组耦合的遗传振荡器在一个伸长的组织，是由扩散和平流信号分子调节可以解释分割作为一个自组织的图案化过程。该系统可以形成有限数量的片段，并且分割的动力学和形成的片段的总数强烈地依赖于描述组织伸长和信号分子的动力学参数。该模型占现有的实验扰动信号梯度，并使新的扰动可测试的预测。在我们的模型中形成的各种不同的模式可以解释不同动物物种之间的分割的可变性。
英文摘要：
Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of cell oscillations with tissue elongation and shortening and with signaling gradients, is still missing. Here we show that a set of coupled genetic oscillators in an elongating tissue that is regulated by diffusing and advected signaling molecules can account for segmentation as a self-organized patterning process. This system can form a finite number of segments and the dynamics of segmentation and the total number of segments formed depend strongly on kinetic parameters describing tissue elongation and signaling molecules. The model accounts for existing experimental perturbations to signaling gradients, and makes testable predictions about novel perturbations. The variety of different patterns formed in our model can account for the variability of segmentation between different animal species.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
