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arXiv 1707.06962cs.LGstat.ML
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基于字典学习和稀疏编码的高分辨率任务功能连接性MRI去噪分析

Dictionary Learning and Sparse Coding-based Denoising for High-Resolution Task Functional Connectivity MRI Analysis

Harvard University(哈佛大学);School of Engineering and Applied Sciences (SEAS)(工程与应用科学学院);Massachusetts General Hospital(麻省总医院);Harvard Medical School(哈佛医学院)

Seongah Jeong, Xiang Li, Jiarui Yang, Quanzheng Li, Vahid Tarokh

摘要:

我们提出了一种新的去噪框架的任务功能磁共振成像(tfMRI)数据,通过字典学习和稀疏编码(DLSC)描绘高分辨率的空间模式的大脑功能连接。为了解决基于DLSC的无监督fMRI研究的局限性,我们在学习步骤中利用任务范式的先验知识来训练数据驱动的字典并对稀疏表示建模。我们将所提出的基于DLSC的方法应用于人类连接组计划(HCP)运动tfMRI数据集。对躯体运动神经网络中小脑神经回路功能连通性的研究表明,与基于时间非局部均值(tNLM)的去噪方法以及不去噪的情况相比,基于DLSC的去噪框架可以显著改善突出的连通性模式,这在运动区内是一致的,具有神经科学意义。实验结果表明,该方法可以为高分辨率的功能连通性分析提供重要的基础,为fMRI预处理提供了一种更好的方法。

英文摘要:

We propose a novel denoising framework for task functional Magnetic Resonance Imaging (tfMRI) data to delineate the high-resolution spatial pattern of the brain functional connectivity via dictionary learning and sparse coding (DLSC). In order to address the limitations of the unsupervised DLSC-based fMRI studies, we utilize the prior knowledge of task paradigm in the learning step to train a data-driven dictionary and to model the sparse representation. We apply the proposed DLSC-based method to Human Connectome Project (HCP) motor tfMRI dataset. Studies on the functional connectivity of cerebrocerebellar circuits in somatomotor networks show that the DLSC-based denoising framework can significantly improve the prominent connectivity patterns, in comparison to the temporal non-local means (tNLM)-based denoising method as well as the case without denoising, which is consistent and neuroscientifically meaningful within motor area. The promising results show that the proposed method can provide an important foundation for the high-resolution functional connectivity analysis, and provide a better approach for fMRI preprocessing.

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