在他们的工作[Proc. Natl. Acad. Sci. USA 112（2015）E5725]，Bosse等人通过实验表明，病毒衣壳在活细胞的细胞核中不仅表现出正常扩散，而且表现出异常扩散。在那里，发现表征它们的扩散指数波动的分布呈现高斯形式，这对于两种不同类型的病毒是非常显著的相同形式。这表明这种波动具有很强的鲁棒性。本文研究了病毒衣壳在细胞核内扩散指数局部波动的统计特性。一个最大熵原理的方法（最初提出了一个不同的病毒在不同的细胞）适用于获得指数的波动分布。根据实验数据，还检查了与染色质间皮层的局部区域识别的块的数量的大。它表明，高斯分布的本地起伏可以推导出，按照上述形式。此外，它是量化的波动分布在一个长的时间尺度上是如何不同于高斯分布。
英文摘要：
In their work [Proc. Natl. Acad. Sci. USA 112 (2015) E5725], Bosse et al. experimentally showed that virus capsid exhibits not only normal diffusion but also anomalous diffusion in nucleus of a living cell. There, it was found that the distribution of fluctuations of the diffusion exponent characterizing them takes the Gaussian form, which is, quite remarkably, the same form for two different types of the virus. This suggests high robustness of such fluctuations. Here, the statistical property of local fluctuations of the diffusion exponent of the virus capsid in the nucleus is studied. A maximum-entropy-principle approach (originally proposed for a different virus in a different cell) is applied for obtaining the fluctuation distribution of the exponent. Largeness of the number of blocks identified with local areas of interchromatin corrals is also examined based on the experimental data. It is shown that the Gaussian distribution of the local fluctuations can be derived, in accordance with the above form. In addition, it is quantified how the fluctuation distribution on a long time scale is different from the Gaussian distribution.
Effects of Rim Fluctuations in Classical Nucleation Theory of Virus Capsids
University of California, Riverside（加州大学河滨分校）；Eindhoven University of Technology（埃因霍温理工大学）；Institut de Physique Théorique, CNRS, CEA, Université Paris-Saclay（巴黎萨克雷大学理论物理研究所）；Great Bay University（大湾区大学）
Mechanical control of the height distribution of adsorbed viral capsids
CNRS, ENS de Lyon（法国国家科学研究中心，里昂高等师范学院）；Molecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon（分子微生物学与结构生物化学联合研究实验室5086，法国国家科学研究中心/里昂大学）；INSERM, Département de la science ouverte（法国国家健康与医学研究院，开放科学部）
