规范对称性与蛋白质结构
Gauge symmetries and structure of proteins
摘要：
我们讨论了蛋白质结构研究的规范场论方法，它允许一种自然的方式来引入集体自由度和非线性拓扑结构。考虑了蛋白质的局部对称性及其在介质中的破缺，导出了蛋白质主链的阿贝尔Higgs模型，其正确折叠由疏水力引起的规范对称破缺定义。在该模型中，蛋白质主链的结构由一维拓扑孤子（扭结）的叠加来定义，这允许以高达1A的精度再现蛋白质主链的三维结构并预测其动力学。
英文摘要：
We discuss the gauge field theory approach to protein structure study, which allows a natural way to introduce collective degrees of freedom and nonlinear topological structures. Local symmetry of proteins and its breaking in the medium is considered, what allows to derive Abelian Higgs model of protein backbone, correct folding of which is defined by gauge symmetry breaking due hydrophobic forces. Within this model structure of protein backbone is defined by superposition of one-dimensional topological solitons (kinks), what allows to reproduce the three-dimensional structure of the protein backbone with precision up to 1A and to predict its dynamics.
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