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arXiv 1612.03217cs.CV
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基于深度神经网络的H&E图像淋巴细胞自动检测

Automatic Lymphocyte Detection in H&E Images with Deep Neural Networks

University of Notre Dame(圣母大学);Ventana Medical Systems, Inc.(Ventana医疗系统公司)

Jianxu Chen, Chukka Srinivas

摘要:

淋巴细胞的自动检测是许多组织图像分析算法中必不可少的第一步。一个准确和鲁棒的自动化淋巴细胞检测方法在计算机科学和临床研究中都是非常重要的。大多数现有的淋巴细胞检测方法都是基于传统的图像处理算法和/或经典的机器学习方法。近年来,深度学习技术从根本上改变了计算机解释图像的方式,并成为各种模式识别问题的无与伦比的解决方案。在这项工作中,我们设计了一个新的深度神经网络模型,该模型通过结合最近几种技术中的思想(如快捷链接)来扩展全卷积网络。此外,我们设计了一个新的培训计划,考虑到有关淋巴细胞的先验知识。该训练方案不仅有效地利用了病理学家提供的有限的自由形式注释,而且自然地支持有效的微调。因此,我们的模型具有通过利用在实际应用中收集的错误来自我改进的潜力。实验结果表明,深度神经网络模型在不同染色条件或不同组织类型的图像中均取得了良好的性能。

英文摘要:

Automatic detection of lymphocyte in H&E images is a necessary first step in lots of tissue image analysis algorithms. An accurate and robust automated lymphocyte detection approach is of great importance in both computer science and clinical studies. Most of the existing approaches for lymphocyte detection are based on traditional image processing algorithms and/or classic machine learning methods. In the recent years, deep learning techniques have fundamentally transformed the way that a computer interprets images and have become a matchless solution in various pattern recognition problems. In this work, we design a new deep neural network model which extends the fully convolutional network by combining the ideas in several recent techniques, such as shortcut links. Also, we design a new training scheme taking the prior knowledge about lymphocytes into consideration. The training scheme not only efficiently exploits the limited amount of free-form annotations from pathologists, but also naturally supports efficient fine-tuning. As a consequence, our model has the potential of self-improvement by leveraging the errors collected during real applications. Our experiments show that our deep neural network model achieves good performance in the images of different staining conditions or different types of tissues.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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