一种用于评估合成电路的资源依赖蛋白质合成模型
A resource dependent protein synthesis model for evaluating synthetic circuits
摘要：
合成基因网络的可靠的计算机设计需要新的方法来模拟有限资源影响下的蛋白质合成过程。我们提出了这样一个新的蛋白质合成模型，它起源于核糖体流动模型，并分别描述了RNA聚合酶和核糖体在mRNA和DNA模板上的运动。通过分析这个模型的收敛特性的基础上的几何考虑，我们提出了额外的见解蛋白质合成过程的动力学机制。此外，我们示范性地展示了如何使用该模型来评估不同负载情况下的合成基因电路的性能。
英文摘要：
Reliable in-silico design of synthetic gene networks necessitates novel approaches to model the process of protein synthesis under the influence of limited resources. We present such a novel protein synthesis model which originates from the Ribosome Flow Model and among other things describes the movement of RNA-polymerase and Ribosomes on mRNA and DNA templates respectively. By analyzing the convergence properties of this model based upon geometric considerations we present additional insights into the dynamic mechanisms of the process of protein synthesis. Further, we exemplarily show how this model can be used to evaluate the performance of synthetic gene circuits under different loading scenarios.
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