细长片状纳米粒子的膜结构
Membrane tubulation by elongated and patchy nanoparticles
摘要：
随着纳米技术的发展，人们对纳米粒子与生物膜的相互作用越来越感兴趣。如果纳米颗粒和膜之间的粘附相互作用补偿了膜弯曲的成本，则纳米颗粒自发地被生物膜包裹。在过去的几年中，在实验和模拟中已经观察到了球形纳米颗粒在膜小管中的合作包裹。对于球形纳米颗粒，颗粒填充的膜小管的稳定性强烈地依赖于粘附性颗粒-膜相互作用的范围。在这篇文章中，我们通过建模和能量最小化表明，细长和片状的颗粒包裹在膜小管，是高度稳定的所有范围内的颗粒-膜相互作用，相比单独包装的颗粒合作。因此，膜小管中细长或片状颗粒的线性链的协同包裹可以提供诱导膜小管形成或将这些颗粒储存在膜中的有效途径。
英文摘要：
Advances in nanotechnology lead to an increasing interest in how nanoparticles interact with biomembranes. Nanoparticles are wrapped spontaneously by biomembranes if the adhesive interactions between the particles and membranes compensate for the cost of membrane bending. In the last years, the cooperative wrapping of spherical nanoparticles in membrane tubules has been observed in experiments and simulations. For spherical nanoparticles, the stability of the particle-filled membrane tubules strongly depends on the range of the adhesive particle-membrane interactions. In this article, we show via modeling and energy minimization that elongated and patchy particles are wrapped cooperatively in membrane tubules that are highly stable for all ranges of the particle-membrane interactions, compared to individual wrapping of the particles. The cooperative wrapping of linear chains of elongated or patchy particles in membrane tubules may thus provide an efficient route to induce membrane tubulation, or to store such particles in membranes.
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