曲率诱导的促炎原和膜微管的膜介导聚集
Membrane mediated aggregation of curvature inducing nematogens and membrane tubulation
摘要：
细胞膜的形状在很大程度上受膜相关的曲率活性蛋白的调节。我们使用一个数值模型的膜与细长的膜夹杂物，最近开发的我们，这可能是不同的沿和垂直于其长轴的自发方向曲率。我们表明，由于膜介导的相互作用，这些曲率诱导膜的致炎剂可以自发地寡聚化，即使在低浓度下，并改变膜的局部形状。我们证明，对于一个大的集团这样的夹杂物，其中两个自发曲率具有相等的符号，管状构象，有时片构象的膜是共同的平衡形状。我们阐明了这些{ \it蛋白晶格}形成所必需的因素。此外，管的弹性性能，如它们的压缩刚度和持久长度的计算。最后，我们讨论了可能的作用，在封盖和分支的管状膜的双向错。
英文摘要：
The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous directional curvatures that could be different along and perpendicular to its long axis. We show that, due to membrane mediated interactions these curvature inducing membrane nematogens can oligomerize spontaneously, even at low concentrations, and change the local shape of the membrane. We demonstrate that for a large group of such inclusions, where the two spontaneous curvatures have equal sign, the tubular conformation and sometime the sheet conformation of the membrane are the common equilibrium shapes. We elucidate the factors necessary for the formation of these {\it protein lattices}. Furthermore, the elastic properties of the tubes, like their compressional stiffness and persistence length are calculated. Finally, we discuss the possible role of nematic disclination in capping and branching of the tubular membranes.
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