无膜细胞器中的序列特异性两性聚电解质相分离
Sequence-specific polyampholyte phase separation in membraneless organelles
摘要：
电荷/芳香富集的内在无序蛋白（IDP）的液液相分离对于无膜细胞器的生物学功能至关重要。这一最新发现的许多物理学原理仍有待阐明。在这里，我们提出了一个理论，在随机相位近似占聚两性电解质相分离的静电效应，产生的预测与最近的实验IDP Ddx 4一致。该理论适用于任何电荷模式，从而为研究IDP相分离的序列依赖性提供了一个通用的分析框架。
英文摘要：
Liquid-liquid phase separation of charge/aromatic-enriched intrinsically disordered proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the physics of this recent discovery remains to be elucidated. Here we present a theory in the random phase approximation to account for electrostatic effects in polyampholyte phase separations, yielding predictions consistent with recent experiments on the IDP Ddx4. The theory is applicable to any charge pattern and thus provides a general analytical framework for studying sequence dependence of IDP phase separation.
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