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arXiv 1605.03751math.STstat.TH
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大型Hi-C数据矩阵的非参数齐性检验和多变点估计

Nonparametric homogeneity tests and multiple change-point estimation for analyzing large Hi-C data matrices

Vincent Brault, Sarah Ouadah, Laure Sansonnet, Céline Lévy-Leduc

摘要:

我们提出了一种新的非参数方法估计的位置的块边界(变点)的非重叠块在随机对称矩阵,其中包括随机变量,其分布从一个块到另一个。我们的方法是基于一个非参数的双样本齐性检验的矩阵,我们扩展到更一般的情况下,几个群体。我们首先提供了一些理论结果,为两个相关的检验统计量,我们解释如何获得变点位置估计。然后,为了支持我们的主张,给出了一些数值实验。最后,我们的方法被应用到Hi-C数据,用于分子生物学,以更好地了解染色体构象对细胞功能的影响。

英文摘要:

We propose a novel nonparametric approach for estimating the location of block boundaries (change-points) of non-overlapping blocks in a random symmetric matrix which consists of random variables having their distribution changing from one block to the other. Our method is based on a nonparametric two-sample homogeneity test for matrices that we extend to the more general case of several groups. We first provide some theoretical results for the two associated test statistics and we explain how to derive change-point location estimators. Then, some numerical experiments are given in order to support our claims. Finally, our approach is applied to Hi-C data which are used in molecular biology for better understanding the influence of the chromosomal conformation on the cells functioning.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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