蛋白质氨基酸突变表中隐藏的热力学信息
Hidden Thermodynamic Information in Protein Amino Acid Mutation Tables
摘要：
我们将基于区块比对的标准1992 20 × 20置换矩阵BL0SUM62与标准1982氨基酸亲水性量表KD以及现代2007亲水性量表MZ相结合，并比较结果。20参数KD和MZ疏水性标度具有不同的热力学特征，分别对应于一级和二级跃迁。KD和MZ比较显示突变率反映了定性氨基酸疏性和亲性二元2x10性质的定量迭代，其定义了四元4x5亚组（但不是五元5x4亚组），现代MZ生物信息学量表给出了更好的结果。四元5聚体MZ 4x5亚组被称为突变子（Mu5）。
英文摘要：
We combine the standard 1992 20x20 substitution matrix based on block alignment, BLOSUM62, with the standard 1982 amino acid hydropathicity scale KD as well as the modern 2007 hydropathicity scale MZ, and compare the results. The 20-parameter KD and MZ hydropathicity scales have different thermodynamic character, corresponding to first and second order transitions. The KD and MZ comparisons show that the mutation rates reflect quantitative iteration of qualitative amino acid phobic and philic binary 2x10 properties that define quaternary 4x5 subgroups (but not quinary 5x4 subgroups), with the modern MZ bioinformatic scale giving much better results. The quaternary 5 mer MZ 4x5 subgroups are called mutons (Mu5).
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