动态键协同性使得滑动表面之间能够非常快速和强烈地结合
Dynamical bond cooperativity enables very fast and strong binding between sliding surfaces
摘要：
协同结合影响生物学中的许多过程，但它通常只在平衡状态下进行。在这项工作中，我们探讨动力学协同驱动系统，合作发生，因为一些债券改变了系统的动态响应的制度，其他债券变得活跃。为了研究这种协同性，我们研究了两个流动驱动的表面之间的摩擦结合，通过大量的激活键相互作用。特别是，我们研究的系统中，每个键可以有两种不同的模式：一种模式对应于一个快速形成但弱键，另一种是一个强大的但缓慢形成的键。我们发现这两种类型的债券相当大的协同性。在某些条件下，系统表现得好像只有一种结合模式，对应于强而快速的成键。我们的研究结果可能有重要的影响摩擦和粘附滑动表面含有互补的结合基序，如在强流动条件下的细胞结合到血管壁的情况下。
英文摘要：
Cooperative binding affects many processes in biology, but it is commonly addressed only in equilibrium. In this work we explore dynamical cooperativity in driven systems, where the cooperation occurs because some of the bonds change the dynamical response of the system to a regime where the other bonds become active. To investigate such cooperativity we study the frictional binding between two flow driven surfaces that interact through a large population of activated bonds. In particular, we study systems where each bond can have two different modes: one mode corresponds to a fast forming yet weak bond, and the other is a strong yet slow forming bond. We find considerable cooperativity between both types of bonds. Under some conditions the system behaves as if there were only one binding mode, corresponding to a strong and fast forming bond. Our results may have important implications on the friction and adhesion between sliding surfaces containing complementary binding motifs, such as in the case of cells binding to the vessel walls under strong flowing conditions.
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