功能化树枝状大分子中宽多分散性的起源及其对癌细胞结合亲和力的影响
Origin of broad polydispersion in functionalized dendrimers and its effects on cancer cell binding affinity
摘要：
具有多个配体的纳米颗粒已被提出用于纳米医学。每个纳米颗粒上的多个靶向配体可以结合到细胞表面上的几个位置，从而促进药物靶向和摄取。实验表明，共轭配体的分布是出乎意料的广泛，解吸速率似乎指数依赖于连接的配体的平均数。这两个发现解释了一个模型，其中配体共轭的纳米粒子具有积极的协同性的$\approx 4kT$，和纳米粒子结合到一个表面上的多个键是永久固定。这推动了对数据的新分析，证实了只有一个解吸的时间常数，即通过单键结合到表面的纳米颗粒。
英文摘要：
Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake. Experiments show that the distribution of conjugated ligands is unexpectedly broad, and the desorption rate appears to depends exponentially upon the mean number of attached ligands. These two findings are explained with a model in which ligands conjugate to the nanoparticle with a positive cooperativity of $\approx 4kT$, and that nanoparticles bound to a surface by multiple bonds are permanently affixed. This drives new analysis of the data, which confirms that there is only one time constant for desorption, that of a nanoparticle bound to the surface by a single bond.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
