DMPC双层膜中丙甲霉素孔的相互作用
Interaction of Alamethicin Pores in DMPC Bilayers
摘要：
我们已经调查了高度对齐的多层膜的两性离子脂质1，2-二肉豆蔻酰-sn-甘油-3-磷脂酰胆碱的抗微生物肽丙甲霉素作为肽/脂质比的函数形成的孔的X-射线散射信号。我们能够获得的孔隙流体的结构因子的信息，然后产生的双层的平面中的孔隙之间的相互作用潜力。除了一个硬核的半径对应于孔的几何半径，我们发现一个排斥性的脂质介导的相互作用的范围为$\simeq 30$和接触值为2.4 $k_BT$。这一结果与最近的理论模型定性一致。
英文摘要：
We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius corresponding to the geometric radius of the pore, we find a repulsive lipid-mediated interaction with a range of $\simeq 30$ Å and a contact value of 2.4 $k_BT$. This result is in qualitative agreement with recent theoretical models.
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