脂质双层中的肽孔：电压促进请求修正模型
Peptide pores in lipid bilayers : voltage facilitation pleads for a revised model
摘要：
我们解决的问题，在脂质双层中创建孔的抗菌肽，专注于电压-温度依赖性的孔开放。两个新的实验（电压钳与alamethicin作为这些肽的象征性代表和在固体/水界面下的电场下的脂质单分子层的中子反射率）用于修正唯一的当前理论模型（H. W. Huang等，Phys. Rev. Lett.，92，198304（2004））。我们介绍了一个一般的贡献的电场作为负责的两个双层小叶的不平衡的张力，我们声称，一个孔开口的主要熵成本是由于相应的“排除面积”的脂质翻译。
英文摘要：
We address the problem of antimicrobial peptides that create pores in lipid bilayers, focusing on voltage-temperature dependence of pore opening. Two novel experiments (voltage-clamp with alamethicin as an emblematic representative of these peptides and neutron reflectivity of lipid-monolayer at solid/water interface under electric field) serve to revise the only current theoretical model (H. W. Huang et al.Phys. Rev. Lett., 92, 198304 (2004)). We introduce a general contribution of the electric field as being responsible for an unbalanced tension of the two bilayer leaflets and we claim that the main entropy cost of one pore opening is due to the corresponding "excluded-area" for lipid translation.
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