arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 1503.07508cs.LGstat.ML
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脑sMRI的稳定特征选择

Stable Feature Selection from Brain sMRI

Yanjing Medical College, Capital Medical University(首都医科大学燕京医学院);Peking University(北京大学)

Bo Xin, Lingjing Hu, Yizhou Wang, Wen Gao

摘要:

神经图像分析通常涉及仅使用有限数量的样本来学习数千甚至数百万个变量。在这方面,稀疏模型,例如套索,被应用于选择最佳特征并实现高诊断准确性。然而,套索通常导致独立的不稳定特征。稳定性是指在数据和模型受到合理扰动的情况下,统计结果的再现性,是统计学中的一个重要焦点,特别是在高维数据的分析中。在本文中,我们探讨了一个非负广义融合套索模型的稳定特征选择在阿尔茨海默病的诊断。除了稀疏性,我们的模型还结合了两个重要的病理先验:病变体素的空间凝聚力和特征与疾病标签之间的正相关性。为了优化模型,我们提出了一个有效的算法,通过证明一个新的链接全变分和快速网络流算法通过圆锥对偶。实验结果表明,该模型通过选择稳定的特征,在挖掘数据的内在结构方面比其他模型有更好的表现。

英文摘要:

Neuroimage analysis usually involves learning thousands or even millions of variables using only a limited number of samples. In this regard, sparse models, e.g. the lasso, are applied to select the optimal features and achieve high diagnosis accuracy. The lasso, however, usually results in independent unstable features. Stability, a manifest of reproducibility of statistical results subject to reasonable perturbations to data and the model, is an important focus in statistics, especially in the analysis of high dimensional data. In this paper, we explore a nonnegative generalized fused lasso model for stable feature selection in the diagnosis of Alzheimer's disease. In addition to sparsity, our model incorporates two important pathological priors: the spatial cohesion of lesion voxels and the positive correlation between the features and the disease labels. To optimize the model, we propose an efficient algorithm by proving a novel link between total variation and fast network flow algorithms via conic duality. Experiments show that the proposed nonnegative model performs much better in exploring the intrinsic structure of data via selecting stable features compared with other state-of-the-arts.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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