三星医疗中心的质子治疗喷嘴：使用TOPAS的蒙特卡罗模拟研究
The Proton Therapy Nozzles at Samsung Medical Center: A Monte Carlo Simulation Study using TOPAS
摘要：
为了加快三星医疗中心（SMC）质子治疗系统的调试过程，我们使用TOPAS开发了质子治疗喷嘴的蒙特卡罗模拟模型。在SMC质子治疗中心，我们有两个机架室，配有不同类型的喷嘴;一个多功能喷嘴和一个专用扫描喷嘴。根据制造商住友重工业株式会社提供的几何信息，对每个喷嘴进行了详细建模。为此，使用了TOPAS的新功能，例如时间功能或脊过滤器类。确定了适合质子喷管模拟的物理模型。剂量学特性，如百分深度剂量曲线，扩展布拉格峰（SOBP），束斑尺寸，已被模拟和验证对测量的束流数据。除了蒙特卡罗喷嘴建模，我们还开发了TOPAS和治疗计划系统（TPS）RayStation之间的接口。从TPS导出的RT计划数据已由界面解释，然后转换为TOPAS输入文本。发展的蒙特卡罗喷嘴模型可以用来估计非束流性能的喷嘴，如中子本底。此外，喷嘴模型可用于研究喷嘴设计中的力学优化。
英文摘要：
To expedite the commissioning process of the proton therapy system at Samsung Medical Center (SMC), we have developed a Monte Carlo simulation model of the proton therapy nozzles using TOPAS. At SMC proton therapy center, we have two gantry rooms with different types of nozzles; a multi-purpose nozzle and a dedicated scanning nozzle. Each nozzle has been modeled in detail following the geometry information provided by the manufacturer, Sumitomo Heavy Industries, Ltd. For this purpose, novel features of TOPAS, such as the time feature or the ridge filter class, have been used. And the appropriate physics models for proton nozzle simulation were defined. Dosimetric properties, like percent depth dose curve, spread-out Bragg peak (SOBP), beam spot size, have been simulated and verified against measured beam data. Beyond the Monte Carlo nozzle modeling, we have developed an interface between TOPAS and the treatment planning system (TPS), RayStation. An exported RT plan data from the TPS has been interpreted by the interface and then translated into the TOPAS input text. The developed Monte Carlo nozzle model can be used to estimate non-beam performance of the nozzles such as the neutron background. Furthermore, the nozzle model can be used to study mechanical optimization in the design of the nozzle.
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