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arXiv 1502.06130math.PR
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自适应随机加筋瓮模型的中心极限定理

Central limit Theorem for an Adaptive Randomly Reinforced Urn Model

Andrea Ghiglietti, Anand N. Vidyashankar, William F. Rosenberger

摘要:

广义Pinglyaurn(GPU)模型及其变体已经在多个学科中进行了研究。然而,相对于GPU所做的典型假设不包括具有对角替换矩阵的骨灰盒模型,其出现在若干应用中,特别是在临床试验中。为了方便在这些应用中的模型的数学分析,我们引入了一个自适应随机增强瓮模型,使用累积的统计信息,自适应地倾斜瓮的比例对特定的目标。我们研究了几个概率方面,在实践中实施瓮模型是很重要的。具体来说,我们建立了大数定律和中心极限定理的抽样球的数量。为了建立这些结果,我们开发了新的技术,涉及最后退出时间和交叉时间分析的比例球在瓮中。为了获得精确的估计,在这些技术中,我们建立结果的总数量的球在瓮的谐波时刻。最后,我们描述了我们的主要结果的背景下,在临床试验中的响应自适应随机化的应用。在这种情况下,我们的模拟实验证明了我们的模型的易用性和范围。

英文摘要:

The generalized Pòlya urn (GPU) models and their variants have been investigated in several disciplines. However, typical assumptions made with respect to the GPU do not include urn models with diagonal replacement matrix, which arise in several applications, specifically in clinical trials. To facilitate mathematical analyses of models in these applications, we introduce an adaptive randomly reinforced urn model that uses accruing statistical information to adaptively skew the urn proportion toward specific targets. We study several probabilistic aspects that are important in implementing the urn model in practice. Specifically, we establish the law of large numbers and a central limit theorem for the number of sampled balls. To establish these results, we develop new techniques involving last exit times and crossing time analyses of the proportion of balls in the urn. To obtain precise estimates in these techniques, we establish results on the harmonic moments of the total number of balls in the urn. Finally, we describe our main results in the context an application to response-adaptive randomization in clinical trials. Our simulation experiments in this context demonstrate the ease and scope of our model.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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