波长超过1500 nm的体内荧光成像
Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
摘要：
与在低于900 nm的可见光和近红外区域中的成像相比，在第二近红外窗口（NIR-II，1000-1700 nm）中的成像是用于体内深层组织高分辨率光学成像的有前途的方法，这主要是由于穿过生物组织的光子的散射减少。本文中，具有大直径的半导体单壁碳纳米管用于在长波长NIR区域（1500-1700 nm，NIR-IIb）中的体内荧光成像。用这种显像剂，可以分辨出3-4 μ m宽的毛细血管，深度约为3 mm。同时，可以同时映射多个单独血管中的血流速度。此外，还探索了活体小鼠的NIR-IIb肿瘤成像。NIR-IIb成像可以推广到发射高达1700 nm的荧光团的广泛范围，以实现高性能的体内光学成像。
英文摘要：
Compared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly due to the reduced scattering of photons traversing through biological tissues. Herein, semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500-1700 nm, NIR-IIb). With this imaging agent, 3-4 um wide capillary blood vessels at a depth of about 3 mm could be resolved. Meanwhile, the blood-flow speeds in multiple individual vessels could be mapped simultaneously. Furthermore, NIR-IIb tumor imaging of a live mouse was explored. NIR-IIb imaging can be generalized to a wide range of fluorophores emitting at up to 1700 nm for high-performance in vivo optical imaging.
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