The mean residual life function is a key functional for a survival distribution. It has a practically useful interpretation as the expected remaining lifetime given survival up to a particular time point, and it also characterizes the survival distribution. However, it has received limited attention in terms of inference methods under a probabilistic modeling framework. We seek to provide general inference methodology for mean residual life regression. We employ Dirichlet process mixture modeling for the joint stochastic mechanism of the covariates and the survival response. This density regression approach implies a flexible model structure for the mean residual life of the conditional response distribution, allowing general shapes for mean residual life as a function of covariates given a specific time point, as well as a function of time given particular values of the covariates. We further extend the mixture model to incorporate dependence across experimental groups. This extension is built from a dependent Dirichlet process prior for the group-specific mixing distributions, with common atoms and weights that vary across groups through latent bivariate Beta distributed random variables. We discuss properties of the regression models, and develop methods for posterior inference. The different components of the methodology are illustrated with simulated data examples, and the model is also applied to a data set comprising right censored survival times.
In the study of life tables the random variable of interest is usually assumed discrete since mortality rates are studied for integer ages. In dynamic life tables a time domain is included to account for the evolution effect of the hazard rates in time. In this article we follow a survival analysis approach and use a nonparametric description of the hazard rates. We construct a discrete time stochastic processes that reflects dependence across age as well as in time. This process is used as a bayesian nonparametric prior distribution for the hazard rates for the study of evolutionary life tabl…
We present a Bayesian nonparametric system reliability model which scales well and provides a great deal of flexibility in modeling. The Bayesian approach naturally handles the disparate amounts of component and subsystem data that may exist. However, traditional Bayesian reliability models are quite computationally complex, relying on MCMC techniques. Our approach utilizes the conjugate properties of the beta-Stacy process, which is the fundamental building block of our model. These individual models are linked together using a method of moments estimation approach. This model is computationa…
Beijing University of Aeronautics and Astronautics（北京航空航天大学）；University of Utah（犹他大学）；Chongqing University（重庆大学）；Beihang University（北京航空航天大学）
Challenges in multi-fidelity modeling relate to accuracy, uncertainty estimation and high-dimensionality. A novel additive structure is introduced in which the highest fidelity solution is written as a sum of the lowest fidelity solution and residuals between the solutions at successive fidelity levels, with Gaussian process priors placed over the low fidelity solution and each of the residuals. The resulting model is equipped with a closed-form solution for the predictive posterior, making it applicable to advanced, high-dimensional tasks that require uncertainty estimation. Its advantages ar…
Based on a novel dynamic Whittle likelihood approximation for locally stationary processes, a Bayesian nonparametric approach to estimating the time-varying spectral density is proposed. This dynamic frequency-domain based likelihood approximation is able to depict the time-frequency evolution of the process by utilizing the moving periodogram previously introduced in the bootstrap literature. The posterior distribution is obtained by updating a bivariate extension of the Bernstein-Dirichlet process prior with the dynamic Whittle likelihood. Asymptotic properties such as sup-norm posterior con…
Bayesian bandwidth estimation for a nonparametric functional regression model with mixed types of regressors and unknown error density
在误差密度未知的框架下，研究了具有函数值、连续实值和离散值回归变量的非参数函数回归模型的带宽估计问题.从Shang（2013，Computational Statistics & Data Analysis）的最近工作扩展，我们通过残差的核密度估计来近似未知误差密度，其中回归函数由允许混合类型回归变量的函数Nadaraya-Watson估计器估计。在核形式误差密度下，推导了带宽参数的核似然和后验密度，提出了一种同时估计带宽的贝叶斯带宽估计方法。仿真研究表明，所提出的贝叶斯方法的回归函数和误差密度的估计精度。以食品质量控制中的光谱数据集为例，我们应用贝叶斯方法来选择具有混合类型回归变量的非参数函数回归模型中的最佳带宽。
The stratified proportional hazards model represents a simple solution to account for heterogeneity within the data while keeping the multiplicative effect on the hazard function. Strata are typically defined a priori by resorting to the values taken by a categorical covariate. A general framework is proposed, which allows for the stratification of a generic accelerated life time model, including as a special case the Weibull proportional hazard model. The stratification is determined a posteriori by taking into account that strata might be characterized by different baseline survivals as well…
The mean past lifetime (MPL) is an important tool in reliability and survival analysis for measuring the average time elapsed since the occurrence of an event, under the condition that the event has occurred before a specific time $t>0$. This article develops a nonparametric estimator for MPL based on observations collected according to ranked set sampling (RSS) design. It is shown that the estimator that we have developed is a strongly uniform consistent. It is also proved that the introduced estimator tends to a Gaussian process under some mild conditions. A Monte Carlo simulation study is e…
Lifelong Learning (LL) refers to the ability to continually learn and solve new problems with incremental available information over time while retaining previous knowledge. Much attention has been given lately to Supervised Lifelong Learning (SLL) with a stream of labelled data. In contrast, we focus on resolving challenges in Unsupervised Lifelong Learning (ULL) with streaming unlabelled data when the data distribution and the unknown class labels evolve over time. Bayesian framework is natural to incorporate past knowledge and sequentially update the belief with new data. We develop a fully…
When to initiate treatment on patients is an important problem in many medical studies such as AIDS and cancer. In this article, we formulate the treatment initiation time problem for time-to-event data and propose an optimal individualized regime that determines the best treatment initiation time for individual patients based on their characteristics. Different from existing optimal treatment regimes where treatments are undertaken at a pre-specified time, here new challenges arise from the complicated missing mechanisms in treatment initiation time data and the continuous treatment rule in t…
Overweight and obesity in adults are known to be associated with risks of metabolic and cardiovascular diseases. Because obesity is an epidemic, increasingly affecting children, it is important to understand if this condition persists from early life to childhood and if different patterns of obesity growth can be detected. Our motivation starts from a study of obesity over time in children from South Eastern Asia. Our main focus is on clustering obesity patterns after adjusting for the effect of baseline information. Specifically, we consider a joint model for height and weight patterns taken …
It is common to assume in empirical research that observables and unobservables are additively separable, especially, when the former are endogenous. This is done because it is widely recognized that identification and estimation challenges arise when interactions between the two are allowed for. Starting from a nonseparable IV model, where the instrumental variable is independent of unobservables, we develop a novel nonparametric test of separability of unobservables. The large-sample distribution of the test statistics is nonstandard and relies on a novel Donsker-type central limit theorem f…
