免疫生物学中的稀有事件模拟：T细胞成熟中的负选择模型
Rare event simulation in immune biology: Models of negative selection in T-cell maturation
摘要：
我们提出了一个概率T细胞模型，包括负选择，并考虑到在胸腺中的组织限制性抗原（TRA）表达的对比模型。我们从van den Berg，Rand和Burroughs（2001）的基本模型开始，并通过基于个体的T细胞建模包括阴性选择，其中每个T细胞由其对所有相关自身抗原的刺激率定义。我们提出了一种模拟方法的基础上，由一个单一的T细胞识别的刺激率的部分倾斜。我们研究了胸腺抗原呈递的不同模式，即任意TRA呈递和组织特异性细胞系的或多或少严格仿真的负选择的影响。我们观察到负选择导致成熟T细胞从自身抗原接收的刺激率分布的尾部截短，即，降低了自身背景。这增加了在非自身抗原存在下单个T细胞的活化概率。
英文摘要：
We present a probabilistic T-cell model that includes negative selection and takes contrasting models of tissue-restricted antigen (TRA) expression in the thymus into account. We start from the basic model of van den Berg, Rand, and Burroughs (2001) and include negative selection via individual-based T-cell modelling, in which each T-cell is defined by its stimulation rates to all relevant self antigens. We present a simulation approach based on partial tilting of the stimulation rates recognized by a single T-cell. We investigate the effects of negative selection for diverging modes of thymic antigen presentation, namely arbitrary TRA presentation, and more or less strict emulation of tissue-specific cell lines. We observe that negative selection leads to truncation of the tail of the distribution of the stimulation rates mature T-cells receive from self antigens, i.e., the self background is reduced. This increases the activation probabilities of single T-cells in the presence of non-self antigens.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
