微管-动粒附着稳定性的构象机制
Conformational mechanism for the stability of microtubule-kinetochore attachments
摘要：
调节微管（MT）-动粒附着的稳定性是避免有丝分裂错误和确保细胞分裂期间正确的染色体分离的基础。虽然参与这一过程的生物化学因素已经确定，但其机制仍需要更好地理解。在这里，我们介绍和模拟MT-动粒相互作用的力学模型，其中的附件的稳定性是由卷曲的MT-原丝缠绕在动粒原纤维的几何构象。该模型使我们能够在体外实验测量中准确地再现酵母动粒在外部拉力下从MT上脱离的时间。数值模拟表明，MT-原丝的几何特征可能在稳定和不稳定的附件之间的切换中发挥重要作用。
英文摘要：
Regulating the stability of microtubule(MT)-kinetochore attachments is fundamental to avoiding mitotic errors and ensure proper chromosome segregation during cell division. While biochemical factors involved in this process have been identified, its mechanics still needs to be better understood. Here we introduce and simulate a mechanical model of MT-kinetochore interactions in which the stability of the attachment is ruled by the geometrical conformations of curling MT-protofilaments entangled in kinetochore fibrils. The model allows us to reproduce with good accuracy in vitro experimental measurements of the detachment times of yeast kinetochores from MTs under external pulling forces. Numerical simulations suggest that geometrical features of MT-protofilaments may play an important role in the switch between stable and unstable attachments.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
