通过DNA环抑制和增强转录噪声
Suppression and enhancement of transcriptional noise by DNA looping
摘要：
已经观察到DNA成环可以增强和抑制转录噪音，但是对于给定的条件，这两种相反的效果中的哪一种是预期的还不确定。在这里，我们推导出的主要量化的转录噪音的分子参数的解析表达式，并阐明DNA循环的作用。我们的研究结果合理化了矛盾的实验观察，并首次定量解释了经典乳糖操纵子遗传系统单分子水平上具有里程碑意义的单个细胞测量结果[Choi et al.，Science 322，442-446（2008）]。
英文摘要：
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi et al., Science 322, 442-446 (2008)].
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