A组轮状病毒NSP4处于负选择压力下
Group A Rotavirus NSP4 is Under Negative Selective Pressure
摘要：
轮状病毒（Rotavirus，RV）是婴幼儿重症胃肠炎的主要病原，其基因组由11段双链RNA组成，编码12种蛋白质。由片段10编码的非结构蛋白4（NSP 4）是多功能的。本研究的目的是通过非同义替换/同义替换的比率（dN/dS）来分析驱动RV的NSP 4的选择压力。我们的结果表明，NSP 4是在负进化压力（84.57%的氨基酸序列）和没有发现的网站，在积极的选择。这可能支持不同RV蛋白或病毒因子的其他进化研究。
英文摘要：
Rotavirus (RV) is the major etiologic agent of severe infantile gastroenteritis; its genome has 11 segments of double stranded RNA, encoding 12 proteins. The non-structural protein 4 (NSP4) encoded by segment 10 is multifunctional. The aim of this study is to analyze the selective pressure driving the NSP4 of RV, through the ratio of non-synonymous substitutions per synonymous substitutions (dN/dS). Our results show that NSP4 is under negative evolutionary pressure (84.57% of the amino acid sequence) and no site was found under positive selection. This may support other evolutionary studies of different RV proteins or viral agents.
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