Mixture model-based clustering has become an increasingly popular data analysis technique since its introduction over fifty years ago, and is now commonly utilized within a family setting. Families of mixture models arise when the component parameters, usually the component covariance (or scale) matrices, are decomposed and a number of constraints are imposed. Within the family setting, model selection involves choosing the member of the family, i.e., the appropriate covariance structure, in addition to the number of mixture components. To date, the Bayesian information criterion (BIC) has proved most effective for model selection, and the expectation-maximization (EM) algorithm is usually used for parameter estimation. In fact, this EM-BIC rubric has virtually monopolized the literature on families of mixture models. Deviating from this rubric, variational Bayes approximations are developed for parameter estimation and the deviance information criterion for model selection. The variational Bayes approach provides an alternate framework for parameter estimation by constructing a tight lower bound on the complex marginal likelihood and maximizing this lower bound by minimizing the associated Kullback-Leibler divergence. This approach is taken on the most commonly used family of Gaussian mixture models, and real and simulated data are used to compare the new approach to the EM-BIC rubric.
Most Item Response Theory (IRT) models for dichotomous responses are based on probit or logit link functions which assume a symmetric relationship between the probability of a correct response and the latent traits of individuals submitted to a test. This assumption restricts the use of those models to the case in which all items have a symmetric behaviour. On the other hand, asymmetric models proposed in the literature impose that all the items in a test have an asymmetric behaviour. This assumption is inappropriate for great part of the tests which are, in general, composed by both symmetric…
We propose a construction for joint feature learning and clustering of multichannel extracellular electrophysiological data across multiple recording periods for action potential detection and discrimination ("spike sorting"). Our construction improves over the previous state-of-the art principally in four ways. First, via sharing information across channels, we can better distinguish between single-unit spikes and artifacts. Second, our proposed "focused mixture model" (FMM) elegantly deals with units appearing, disappearing, or reappearing over multiple recording days, an important considera…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Adobe Systems, Inc.（奥多比系统公司）；Analog Devices（亚德诺半导体）
In this paper, we develop a parameter estimation method for factorially parametrized models such as Factorial Gaussian Mixture Model and Factorial Hidden Markov Model. Our contributions are two-fold. First, we show that the emission matrix of the standard Factorial Model is unidentifiable even if the true assignment matrix is known. Secondly, we address the issue of identifiability by making a one component sharing assumption and derive a parameter learning algorithm for this case. Our approach is based on a dictionary learning problem of the form $X = O R$, where the goal is to learn the dict…
In regression models, predictor variables with inherent ordering, such as tumor staging ranging and ECOG performance status, are commonly seen in medical settings. Statistically, it may be difficult to determine the functional form of an ordinal predictor variable. Often, such a variable is dichotomized based on whether it is above or below a certain cutoff. Other methods conveniently treat the ordinal predictor as a continuous variable and assume a linear relationship with the outcome. However, arbitrarily choosing a method may lead to inaccurate inference and treatment. In this paper, we pro…
The paper proposes a latent variable model for binary data coming from an unobserved heterogeneous population. The heterogeneity is taken into account by replacing the traditional assumption of Gaussian distributed factors by a finite mixture of multivariate Gaussians. The aim of the proposed model is twofold: it allows to achieve dimension reduction when the data are dichotomous and, simultaneously, it performs model based clustering in the latent space. Model estimation is obtained by means of a maximum likelihood method via a generalized version of the EM algorithm. In order to evaluate the…
Motivated by the analysis of a Positron Emission Tomography (PET) imaging data considered in Bowen et al. (2012), we introduce a semiparametric topographical mixture model able to capture the characteristics of dichotomous shifted response-type experiments. We propose a local estimation procedure, based on the symmetry of the local noise, for the proportion and locations functions involved in the proposed model. We establish under mild conditions the minimax properties and asymptotic normality of our estimators when Monte Carlo simulations are conducted to examine their finite sample performan…
We propose a kernel mixture of polynomials prior for Bayesian nonparametric regression. The regression function is modeled by local averages of polynomials with kernel mixture weights. We obtain the minimax-optimal rate of contraction of the full posterior distribution up to a logarithmic factor that adapts to the smoothness level of the true function by estimating metric entropies of certain function classes. We also provide a frequentist sieve maximum likelihood estimator with a near-optimal convergence rate. We further investigate the application of the kernel mixture of polynomials to the …
Traditional Item Response Theory models assume the distribution of the abilities of the population in study to be Gaussian. However, this may not always be a reasonable assumption, which motivates the development of more general models. This paper presents a generalised approach for the distribution of the abilities in dichotomous 3-parameter Item Response models. A mixture of normal distributions is considered, allowing for features like skewness, multimodality and heavy tails. A solution is proposed to deal with model identifiability issues without compromising the flexibility and practical …
There is wide interest in studying how the distribution of a continuous response changes with a predictor. We are motivated by environmental applications in which the predictor is the dose of an exposure and the response is a health outcome. A main focus in these studies is inference on dose levels associated with a given increase in risk relative to a baseline. Popular methods either dichotomize the continuous response or focus on modeling changes with the dose in the expectation of the outcome. Such choices may lead to information loss and provide inaccurate inference on dose-response relati…
This paper addresses the problem of identifying a lower dimensional space where observed data can be sparsely represented. This under-complete dictionary learning task can be formulated as a blind separation problem of sparse sources linearly mixed with an unknown orthogonal mixing matrix. This issue is formulated in a Bayesian framework. First, the unknown sparse sources are modeled as Bernoulli-Gaussian processes. To promote sparsity, a weighted mixture of an atom at zero and a Gaussian distribution is proposed as prior distribution for the unobserved sources. A non-informative prior distrib…
This paper introduces a flexible Bayesian nonparametric Item Response Theory (IRT) model, which applies to dichotomous or polytomous item responses, and which can apply to either unidimensional or multidimensional scaling. This is an infinite-mixture IRT model, with person ability and item difficulty parameters, and with a random intercept parameter that is assigned a mixing distribution, with mixing weights a probit function of other person and item parameters. As a result of its flexibility, the Bayesian nonparametric IRT model can provide outlier-robust estimation of the person ability para…
Although Bayesian density estimation using discrete mixtures has good performance in modest dimensions, there is a lack of statistical and computational scalability to high-dimensional multivariate cases. To combat the curse of dimensionality, it is necessary to assume the data are concentrated near a lower-dimensional subspace. However, Bayesian methods for learning this subspace along with the density of the data scale poorly computationally. To solve this problem, we propose an empirical Bayes approach, which estimates a multiscale dictionary using geometric multiresolution analysis in a fi…
