距离很重要：基因邻近性对细菌基因调控的影响
Distance matters: the impact of gene proximity in bacterial gene regulation
摘要：
随着最近发现下游调控基因在活细胞中的共定位，这些基因之间的空间距离对基因产物形成动力学的影响越来越被认识到。我们在这里从分析和数值分析表明，转录因子（TF）基因和它的靶基因之间的距离极大地影响了细菌细胞中转录调控的速度和可靠性。对于一个明确的模型系统，我们开发了一个TF和转录单位之间的相互作用的一般理论。观察到的调节效率的变化与TF浓度峰的变化幅度相关，TF浓度峰的变化幅度是与信号源的结合位点距离的函数。我们的研究结果支持快速结合位点搜索基因共定位的作用，并强调局部浓度差异的作用。
英文摘要：
Following recent discoveries of colocalization of downstream-regulating genes in living cells, the impact of the spatial distance between such genes on the kinetics of gene product formation is increasingly recognized. We here show from analytical and numerical analysis that the distance between a transcription factor (TF) gene and its target gene drastically affects the speed and reliability of transcriptional regulation in bacterial cells. For an explicit model system we develop a general theory for the interactions between a TF and a transcription unit. The observed variations in regulation efficiency are linked to the magnitude of the variation of the TF concentration peaks as a function of the binding site distance from the signal source. Our results support the role of rapid binding site search for gene colocalization and emphasize the role of local concentration differences.
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